Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice
Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618300501 |
| _version_ | 1818723449212764160 |
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| author | Cuicui Duan Yujuan Zhao Cheng Huang Zijian Zhao Lei Gao Chunhua Niu Chao Wang Xiaoxiao Liu Chuan Zhang Shengyu Li |
| author_facet | Cuicui Duan Yujuan Zhao Cheng Huang Zijian Zhao Lei Gao Chunhua Niu Chao Wang Xiaoxiao Liu Chuan Zhang Shengyu Li |
| author_sort | Cuicui Duan |
| collection | DOAJ |
| description | Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN–induced liver injury. L. plantarum C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-κB nuclear translocations and P65, P38 phosphorylation levels. Moreover, L. plantarum C88 enhanced the intestinal mucosal barrier by upregulating the expressions of tight junction proteins as well as HIF-1α. These results suggest that L. plantarum C88 protects against ALF associated with Nrf2 and the MAPK/NF-κB signaling pathways. |
| first_indexed | 2024-12-17T21:10:42Z |
| format | Article |
| id | doaj.art-4f7366e15e2a4451b36af3d189bc323c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:10:42Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-4f7366e15e2a4451b36af3d189bc323c2022-12-21T21:32:28ZengElsevierJournal of Functional Foods1756-46462018-04-0143146153Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in miceCuicui Duan0Yujuan Zhao1Cheng Huang2Zijian Zhao3Lei Gao4Chunhua Niu5Chao Wang6Xiaoxiao Liu7Chuan Zhang8Shengyu Li9Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agricultural Quality Standard and Testing Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaDepartment of Endocrinology, The Second Hospital of Jilin University, Changchun 130000, PR China; Corresponding authors at: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, No. 1363 Sheng-Tai Street, Changchun, Jilin Province 130033, PR China (S. Li). Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin Province, PR China (C. Zhang).Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China; Corresponding authors at: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, No. 1363 Sheng-Tai Street, Changchun, Jilin Province 130033, PR China (S. Li). Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin Province, PR China (C. Zhang).Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN–induced liver injury. L. plantarum C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-κB nuclear translocations and P65, P38 phosphorylation levels. Moreover, L. plantarum C88 enhanced the intestinal mucosal barrier by upregulating the expressions of tight junction proteins as well as HIF-1α. These results suggest that L. plantarum C88 protects against ALF associated with Nrf2 and the MAPK/NF-κB signaling pathways.http://www.sciencedirect.com/science/article/pii/S1756464618300501Lactobacillus plantarumHepatoprotectiveAntioxidationAnti-inflammationIntestinal barrier |
| spellingShingle | Cuicui Duan Yujuan Zhao Cheng Huang Zijian Zhao Lei Gao Chunhua Niu Chao Wang Xiaoxiao Liu Chuan Zhang Shengyu Li Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice Journal of Functional Foods Lactobacillus plantarum Hepatoprotective Antioxidation Anti-inflammation Intestinal barrier |
| title | Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice |
| title_full | Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice |
| title_fullStr | Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice |
| title_full_unstemmed | Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice |
| title_short | Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice |
| title_sort | hepatoprotective effects of lactobacillus plantarum c88 on lps d galn induced acute liver injury in mice |
| topic | Lactobacillus plantarum Hepatoprotective Antioxidation Anti-inflammation Intestinal barrier |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618300501 |
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