Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters
Abstract Background Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Method...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12986-020-00497-1 |
| _version_ | 1811293511268433920 |
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| author | Philip J. Prins Dominic P. D’Agostino Christopher Q. Rogers Dana L. Ault Gary L. Welton Dalton W. Jones Samuel R. Henson Tyler J. Rothfuss Kylie G. Aiken Jantzen L. Hose Emilia L. England Adam D. Atwell Jeffrey D. Buxton Andrew P. Koutnik |
| author_facet | Philip J. Prins Dominic P. D’Agostino Christopher Q. Rogers Dana L. Ault Gary L. Welton Dalton W. Jones Samuel R. Henson Tyler J. Rothfuss Kylie G. Aiken Jantzen L. Hose Emilia L. England Adam D. Atwell Jeffrey D. Buxton Andrew P. Koutnik |
| author_sort | Philip J. Prins |
| collection | DOAJ |
| description | Abstract Background Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods Thirteen recreational male distance runners (24.8 ± 9.6 years, 72.5 ± 8.3 kg, VO2max 60.1 ± 5.4 ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1: 22.1 g) or two (KS2: 44.2 g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 and 60 min), post-exercise (+ 0 min, + 15 min). Time, heart rate (HR), rating of perceived exertion (RPE), affect, respiratory exchange ratio, oxygen consumption (VO2), carbon dioxide production, and ventilation were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, HR, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion Novel βHB + MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, HR, affect, RPE, and exercise performance. |
| first_indexed | 2024-04-13T05:02:25Z |
| format | Article |
| id | doaj.art-4f74f02f5cbd421fa2c444ef51cce003 |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-04-13T05:02:25Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-4f74f02f5cbd421fa2c444ef51cce0032022-12-22T03:01:17ZengBMCNutrition & Metabolism1743-70752020-09-0117111210.1186/s12986-020-00497-1Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parametersPhilip J. Prins0Dominic P. D’Agostino1Christopher Q. Rogers2Dana L. Ault3Gary L. Welton4Dalton W. Jones5Samuel R. Henson6Tyler J. Rothfuss7Kylie G. Aiken8Jantzen L. Hose9Emilia L. England10Adam D. Atwell11Jeffrey D. Buxton12Andrew P. Koutnik13Department of Exercise Science, Grove City CollegeDepartment of Molecular Pharmacology and Physiology, University of South FloridaDepartment of Molecular Pharmacology and Physiology, University of South FloridaDepartment of Exercise Science, Grove City CollegeDepartment of Psychology, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Exercise Science, Grove City CollegeDepartment of Molecular Pharmacology and Physiology, University of South FloridaAbstract Background Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods Thirteen recreational male distance runners (24.8 ± 9.6 years, 72.5 ± 8.3 kg, VO2max 60.1 ± 5.4 ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1: 22.1 g) or two (KS2: 44.2 g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 and 60 min), post-exercise (+ 0 min, + 15 min). Time, heart rate (HR), rating of perceived exertion (RPE), affect, respiratory exchange ratio, oxygen consumption (VO2), carbon dioxide production, and ventilation were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, HR, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion Novel βHB + MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, HR, affect, RPE, and exercise performance.http://link.springer.com/article/10.1186/s12986-020-00497-1Ketone bodiesKetogenicBeta hydroxybutyrateMedium chain triglyceridesPerformanceCognition |
| spellingShingle | Philip J. Prins Dominic P. D’Agostino Christopher Q. Rogers Dana L. Ault Gary L. Welton Dalton W. Jones Samuel R. Henson Tyler J. Rothfuss Kylie G. Aiken Jantzen L. Hose Emilia L. England Adam D. Atwell Jeffrey D. Buxton Andrew P. Koutnik Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters Nutrition & Metabolism Ketone bodies Ketogenic Beta hydroxybutyrate Medium chain triglycerides Performance Cognition |
| title | Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters |
| title_full | Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters |
| title_fullStr | Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters |
| title_full_unstemmed | Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters |
| title_short | Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters |
| title_sort | dose response of a novel exogenous ketone supplement on physiological perceptual and performance parameters |
| topic | Ketone bodies Ketogenic Beta hydroxybutyrate Medium chain triglycerides Performance Cognition |
| url | http://link.springer.com/article/10.1186/s12986-020-00497-1 |
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