Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone
Osteoporosis, a chronic bone disorder, is one of the leading causes of fracture and morbidity risk. Numerous medicinally important herbs have been evaluated for their efficacy in improving bone mass density in exhaustive preclinical and limited clinical studies. <i>Nigella sativa</i> L....
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/11/631 |
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| author | Javed Ahmad Hassan A. Albarqi Mohammad Zaki Ahmad Mohamed A. A. Orabi Shadab Md Ritam Bandopadhyay Faraha Ahmed Mohammad Ahmed Khan Javed Ahamad Awanish Mishra |
| author_facet | Javed Ahmad Hassan A. Albarqi Mohammad Zaki Ahmad Mohamed A. A. Orabi Shadab Md Ritam Bandopadhyay Faraha Ahmed Mohammad Ahmed Khan Javed Ahamad Awanish Mishra |
| author_sort | Javed Ahmad |
| collection | DOAJ |
| description | Osteoporosis, a chronic bone disorder, is one of the leading causes of fracture and morbidity risk. Numerous medicinally important herbs have been evaluated for their efficacy in improving bone mass density in exhaustive preclinical and limited clinical studies. <i>Nigella sativa</i> L. has been used as local folk medicine, and traditional healers have used it to manage various ailments. Its reported beneficial effects include controlling bone and joint diseases. The present manuscript aimed to provide a sound discussion on the pharmacological evidence of <i>N. sativa</i> and its active constituent, thymoquinone, for its utility in the effective management of osteoporosis. <i>N. sativa</i> is reported to possess anti-IL-1 and anti-TNF-<i>α</i>-mediated anti-inflammatory effects, leading to positive effects on bone turnover markers, such as alkaline phosphatase and tartrate-resistant acid phosphatase. It is reported to stimulate bone regeneration by prompting osteoblast proliferation, ossification, and decreasing osteoclast cells. Thymoquinone from <i>N. sativa</i> has exhibited an antioxidant effect on bone tissue by reducing the FeNTA-induced oxidative stress. The present manuscript highlights phytochemistry, pharmacological effect, and the important mechanistic perspective of <i>N. sativa</i> and its active constituents for the management of osteoporosis. Further, it also provides sound discussion on the utilization of a nanotechnology-mediated drug delivery approach as a promising strategy to improve the therapeutic performance of <i>N. sativa</i> and its active constituent, thymoquinone, in the effective management of osteoporosis. |
| first_indexed | 2024-03-09T19:16:02Z |
| format | Article |
| id | doaj.art-4f75b40a519b400e86463e6ff6ed85d0 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T19:16:02Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-4f75b40a519b400e86463e6ff6ed85d02023-11-24T03:46:23ZengMDPI AGBioengineering2306-53542022-11-0191163110.3390/bioengineering9110631Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent ThymoquinoneJaved Ahmad0Hassan A. Albarqi1Mohammad Zaki Ahmad2Mohamed A. A. Orabi3Shadab Md4Ritam Bandopadhyay5Faraha Ahmed6Mohammad Ahmed Khan7Javed Ahamad8Awanish Mishra9Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar 110062, New Delhi, IndiaDepartment of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar 110062, New Delhi, IndiaDepartment of Pharmacognosy, Faculty of Pharmacy, Tishk International University, Erbil 44001, IraqDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)–Guwahati, Changsari, Kamrup 781101, Assam, IndiaOsteoporosis, a chronic bone disorder, is one of the leading causes of fracture and morbidity risk. Numerous medicinally important herbs have been evaluated for their efficacy in improving bone mass density in exhaustive preclinical and limited clinical studies. <i>Nigella sativa</i> L. has been used as local folk medicine, and traditional healers have used it to manage various ailments. Its reported beneficial effects include controlling bone and joint diseases. The present manuscript aimed to provide a sound discussion on the pharmacological evidence of <i>N. sativa</i> and its active constituent, thymoquinone, for its utility in the effective management of osteoporosis. <i>N. sativa</i> is reported to possess anti-IL-1 and anti-TNF-<i>α</i>-mediated anti-inflammatory effects, leading to positive effects on bone turnover markers, such as alkaline phosphatase and tartrate-resistant acid phosphatase. It is reported to stimulate bone regeneration by prompting osteoblast proliferation, ossification, and decreasing osteoclast cells. Thymoquinone from <i>N. sativa</i> has exhibited an antioxidant effect on bone tissue by reducing the FeNTA-induced oxidative stress. The present manuscript highlights phytochemistry, pharmacological effect, and the important mechanistic perspective of <i>N. sativa</i> and its active constituents for the management of osteoporosis. Further, it also provides sound discussion on the utilization of a nanotechnology-mediated drug delivery approach as a promising strategy to improve the therapeutic performance of <i>N. sativa</i> and its active constituent, thymoquinone, in the effective management of osteoporosis.https://www.mdpi.com/2306-5354/9/11/631<i>Nigella sativa</i>thymoquinonenano-thymoquinoneantioxidantanti-inflammatoryosteoporosis |
| spellingShingle | Javed Ahmad Hassan A. Albarqi Mohammad Zaki Ahmad Mohamed A. A. Orabi Shadab Md Ritam Bandopadhyay Faraha Ahmed Mohammad Ahmed Khan Javed Ahamad Awanish Mishra Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone Bioengineering <i>Nigella sativa</i> thymoquinone nano-thymoquinone antioxidant anti-inflammatory osteoporosis |
| title | Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone |
| title_full | Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone |
| title_fullStr | Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone |
| title_full_unstemmed | Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone |
| title_short | Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting <i>Nigella sativa</i> and Its Active Constituent Thymoquinone |
| title_sort | utilization of nanotechnology to improve bone health in osteoporosis exploiting i nigella sativa i and its active constituent thymoquinone |
| topic | <i>Nigella sativa</i> thymoquinone nano-thymoquinone antioxidant anti-inflammatory osteoporosis |
| url | https://www.mdpi.com/2306-5354/9/11/631 |
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