Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities
Purpose: Radioembolization is an alternative palliative treatment for hepatocellular carcinoma. Here, we examine the uptake differences between tumor tissue phenotypes and present a cross-section of the absorbed dose throughout a liver tissue specimen. Methods and materials: A patient with hepatocel...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-07-01
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| Series: | Advances in Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245210941830071X |
| _version_ | 1811302554747797504 |
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| author | Jens Hemmingsson, MS Jonas Högberg, PhD Johan Mölne, MD, PhD Johanna Svensson, MD, PhD Peter Gjertsson, MD, PhD Magnus Rizell, MD, PhD Olof Henrikson, MD, PhD Peter Bernhardt, PhD |
| author_facet | Jens Hemmingsson, MS Jonas Högberg, PhD Johan Mölne, MD, PhD Johanna Svensson, MD, PhD Peter Gjertsson, MD, PhD Magnus Rizell, MD, PhD Olof Henrikson, MD, PhD Peter Bernhardt, PhD |
| author_sort | Jens Hemmingsson, MS |
| collection | DOAJ |
| description | Purpose: Radioembolization is an alternative palliative treatment for hepatocellular carcinoma. Here, we examine the uptake differences between tumor tissue phenotypes and present a cross-section of the absorbed dose throughout a liver tissue specimen. Methods and materials: A patient with hepatocellular carcinoma was treated with 90Y radioembolization followed by liver tissue resection. Gamma camera images and autoradiographs were collected and biopsy tissue samples were analyzed using a gamma well counter and light microscopy. Results: An analysis of 25 punched biopsy tissue samples identified 4 tissue regions: Normal tissue, viable tumor tissue with and without infarcted areas, and tumor areas with postnecrotic scar tissue. Autoradiography and biopsy tissue sample measurements showed large dose differences between viable and postnecrotic tumor tissue (159 Gy vs 23 Gy). Conclusions: Radioembolization of 90 yttrium with resin microspheres produces heterogeneous-absorbed dose distributions in the treatment of unifocal hepatic malignancies that could not be accurately determined with current gamma camera imaging techniques. |
| first_indexed | 2024-04-13T07:31:03Z |
| format | Article |
| id | doaj.art-4f79431be566436a8bbbf5d497d7c7d4 |
| institution | Directory Open Access Journal |
| issn | 2452-1094 |
| language | English |
| last_indexed | 2024-04-13T07:31:03Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Radiation Oncology |
| spelling | doaj.art-4f79431be566436a8bbbf5d497d7c7d42022-12-22T02:56:21ZengElsevierAdvances in Radiation Oncology2452-10942018-07-0133439446Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneitiesJens Hemmingsson, MS0Jonas Högberg, PhD1Johan Mölne, MD, PhD2Johanna Svensson, MD, PhD3Peter Gjertsson, MD, PhD4Magnus Rizell, MD, PhD5Olof Henrikson, MD, PhD6Peter Bernhardt, PhD7Department of Radiation Physics, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden; Corresponding author. Department of Radiation Physics, Sahlgrenska University Hospital, Gula Stråket 2B, Gothenburg 41345, Sweden.Department of Medical Physics, Linköping University Hospital, Linköping, SwedenDepartment of Pathology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Oncology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Clinical Physiology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Surgery, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Radiology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Radiation Physics, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, SwedenPurpose: Radioembolization is an alternative palliative treatment for hepatocellular carcinoma. Here, we examine the uptake differences between tumor tissue phenotypes and present a cross-section of the absorbed dose throughout a liver tissue specimen. Methods and materials: A patient with hepatocellular carcinoma was treated with 90Y radioembolization followed by liver tissue resection. Gamma camera images and autoradiographs were collected and biopsy tissue samples were analyzed using a gamma well counter and light microscopy. Results: An analysis of 25 punched biopsy tissue samples identified 4 tissue regions: Normal tissue, viable tumor tissue with and without infarcted areas, and tumor areas with postnecrotic scar tissue. Autoradiography and biopsy tissue sample measurements showed large dose differences between viable and postnecrotic tumor tissue (159 Gy vs 23 Gy). Conclusions: Radioembolization of 90 yttrium with resin microspheres produces heterogeneous-absorbed dose distributions in the treatment of unifocal hepatic malignancies that could not be accurately determined with current gamma camera imaging techniques.http://www.sciencedirect.com/science/article/pii/S245210941830071X |
| spellingShingle | Jens Hemmingsson, MS Jonas Högberg, PhD Johan Mölne, MD, PhD Johanna Svensson, MD, PhD Peter Gjertsson, MD, PhD Magnus Rizell, MD, PhD Olof Henrikson, MD, PhD Peter Bernhardt, PhD Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities Advances in Radiation Oncology |
| title | Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities |
| title_full | Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities |
| title_fullStr | Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities |
| title_full_unstemmed | Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities |
| title_short | Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities |
| title_sort | autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities |
| url | http://www.sciencedirect.com/science/article/pii/S245210941830071X |
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