Protein cargo in extracellular vesicles as the key mediator in the progression of cancer
Abstract Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01408-6 |
| _version_ | 1827382060004671488 |
|---|---|
| author | Klára Hánělová Martina Raudenská Michal Masařík Jan Balvan |
| author_facet | Klára Hánělová Martina Raudenská Michal Masařík Jan Balvan |
| author_sort | Klára Hánělová |
| collection | DOAJ |
| description | Abstract Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. The unique exosome biogenesis, composition, nontoxicity, and ability to target specific tumour cells bring up their use as promising drug carriers and cancer biomarkers. In this review, we focus on the role of exosomes, with an emphasis on their protein cargo, in the key mechanisms promoting cancer progression. We also briefly summarise the mechanism of exosome biogenesis, its structure, protein composition, and potential as a signalling hub in both normal and pathological conditions. Video Abstract |
| first_indexed | 2024-03-08T14:14:02Z |
| format | Article |
| id | doaj.art-4f797babadbd46bcac18dc8d1526ca3a |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-08T14:14:02Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-4f797babadbd46bcac18dc8d1526ca3a2024-01-14T12:30:24ZengBMCCell Communication and Signaling1478-811X2024-01-0122112010.1186/s12964-023-01408-6Protein cargo in extracellular vesicles as the key mediator in the progression of cancerKlára Hánělová0Martina Raudenská1Michal Masařík2Jan Balvan3Department of Pathological Physiology, Faculty of Medicine, Masaryk UniversityDepartment of Pathological Physiology, Faculty of Medicine, Masaryk UniversityDepartment of Pathological Physiology, Faculty of Medicine, Masaryk UniversityDepartment of Pathological Physiology, Faculty of Medicine, Masaryk UniversityAbstract Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. The unique exosome biogenesis, composition, nontoxicity, and ability to target specific tumour cells bring up their use as promising drug carriers and cancer biomarkers. In this review, we focus on the role of exosomes, with an emphasis on their protein cargo, in the key mechanisms promoting cancer progression. We also briefly summarise the mechanism of exosome biogenesis, its structure, protein composition, and potential as a signalling hub in both normal and pathological conditions. Video Abstracthttps://doi.org/10.1186/s12964-023-01408-6Extracellular vesiclesExosomesExosomal proteinsCancerTumour microenvironmentCancer-associated fibroblasts |
| spellingShingle | Klára Hánělová Martina Raudenská Michal Masařík Jan Balvan Protein cargo in extracellular vesicles as the key mediator in the progression of cancer Cell Communication and Signaling Extracellular vesicles Exosomes Exosomal proteins Cancer Tumour microenvironment Cancer-associated fibroblasts |
| title | Protein cargo in extracellular vesicles as the key mediator in the progression of cancer |
| title_full | Protein cargo in extracellular vesicles as the key mediator in the progression of cancer |
| title_fullStr | Protein cargo in extracellular vesicles as the key mediator in the progression of cancer |
| title_full_unstemmed | Protein cargo in extracellular vesicles as the key mediator in the progression of cancer |
| title_short | Protein cargo in extracellular vesicles as the key mediator in the progression of cancer |
| title_sort | protein cargo in extracellular vesicles as the key mediator in the progression of cancer |
| topic | Extracellular vesicles Exosomes Exosomal proteins Cancer Tumour microenvironment Cancer-associated fibroblasts |
| url | https://doi.org/10.1186/s12964-023-01408-6 |
| work_keys_str_mv | AT klarahanelova proteincargoinextracellularvesiclesasthekeymediatorintheprogressionofcancer AT martinaraudenska proteincargoinextracellularvesiclesasthekeymediatorintheprogressionofcancer AT michalmasarik proteincargoinextracellularvesiclesasthekeymediatorintheprogressionofcancer AT janbalvan proteincargoinextracellularvesiclesasthekeymediatorintheprogressionofcancer |