Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis
Notch signaling is an evolutionarily conserved pathway regulating normal embryonic development and homeostasis in a wide variety of tissues. It is also critically involved in carcinogenesis, as well as cancer progression. Activation of the Notch pathway members can be either oncogenic or suppressive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/4/768 |
| _version_ | 1797396780023808000 |
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| author | Dorota Anusewicz Magdalena Orzechowska Andrzej K. Bednarek |
| author_facet | Dorota Anusewicz Magdalena Orzechowska Andrzej K. Bednarek |
| author_sort | Dorota Anusewicz |
| collection | DOAJ |
| description | Notch signaling is an evolutionarily conserved pathway regulating normal embryonic development and homeostasis in a wide variety of tissues. It is also critically involved in carcinogenesis, as well as cancer progression. Activation of the Notch pathway members can be either oncogenic or suppressive, depending on tissue context. The present study is a comprehensive overview, extended with a bioinformatics analysis of TCGA cohorts, including breast, bladder, cervical, colon, kidney, lung, ovary, prostate and rectum carcinomas. We performed global expression profiling of the Notch pathway core components and downstream targets. For this purpose, we implemented the Uniform Manifold Approximation and Projection algorithm to reduce the dimensions. Furthermore, we determined the optimal cutpoint using Evaluate Cutpoint software to established disease-free and overall survival with respect to particular Notch members. Our results demonstrated separation between tumors and their corresponding normal tissue, as well as between tumors in general. The differentiation of the Notch pathway, at its various stages, in terms of expression and survival resulted in distinct profiles of biological processes such as proliferation, adhesion, apoptosis and epithelial to mesenchymal transition. In conclusion, whether oncogenic or suppressive, Notch signaling is proven to be associated with various types of malignancies, and thus may be of interest as a potential therapeutic target. |
| first_indexed | 2024-03-09T00:56:28Z |
| format | Article |
| id | doaj.art-4f7a9e964fba47a8a96d368175c4519d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T00:56:28Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4f7a9e964fba47a8a96d368175c4519d2023-12-11T16:51:18ZengMDPI AGCancers2072-66942021-02-0113476810.3390/cancers13040768Notch Signaling Pathway in Cancer—Review with Bioinformatic AnalysisDorota Anusewicz0Magdalena Orzechowska1Andrzej K. Bednarek2Department of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, PolandDepartment of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, PolandDepartment of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, PolandNotch signaling is an evolutionarily conserved pathway regulating normal embryonic development and homeostasis in a wide variety of tissues. It is also critically involved in carcinogenesis, as well as cancer progression. Activation of the Notch pathway members can be either oncogenic or suppressive, depending on tissue context. The present study is a comprehensive overview, extended with a bioinformatics analysis of TCGA cohorts, including breast, bladder, cervical, colon, kidney, lung, ovary, prostate and rectum carcinomas. We performed global expression profiling of the Notch pathway core components and downstream targets. For this purpose, we implemented the Uniform Manifold Approximation and Projection algorithm to reduce the dimensions. Furthermore, we determined the optimal cutpoint using Evaluate Cutpoint software to established disease-free and overall survival with respect to particular Notch members. Our results demonstrated separation between tumors and their corresponding normal tissue, as well as between tumors in general. The differentiation of the Notch pathway, at its various stages, in terms of expression and survival resulted in distinct profiles of biological processes such as proliferation, adhesion, apoptosis and epithelial to mesenchymal transition. In conclusion, whether oncogenic or suppressive, Notch signaling is proven to be associated with various types of malignancies, and thus may be of interest as a potential therapeutic target.https://www.mdpi.com/2072-6694/13/4/768Notch signalingcarcinogenesisglobal signaling |
| spellingShingle | Dorota Anusewicz Magdalena Orzechowska Andrzej K. Bednarek Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis Cancers Notch signaling carcinogenesis global signaling |
| title | Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis |
| title_full | Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis |
| title_fullStr | Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis |
| title_full_unstemmed | Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis |
| title_short | Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis |
| title_sort | notch signaling pathway in cancer review with bioinformatic analysis |
| topic | Notch signaling carcinogenesis global signaling |
| url | https://www.mdpi.com/2072-6694/13/4/768 |
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