PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy?
AIMS: The aim of this study was to investigate the relationship between Ki- 67 proliferation index and prognosis in primary angiosarcoma of the breast (PAB). Hormonal status of PAB was also discussed, since PAB sometimes can be seen with coexistent pregnancy.METHODS: During a 17-year period 4 cases...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2006-07-01
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| Series: | European Journal of Breast Health |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/prmary-angosarcoma-of-the-breast-s-k-67-proliferat/42717
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| _version_ | 1797909327012429824 |
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| author | Yasemin Özlük Sıtkı Tuzlalı Ekrem Yavuz Duygu Derin Oktar Asoğlu Abdullah İğci Rıdvan İlhan Altan İplikçi |
| author_facet | Yasemin Özlük Sıtkı Tuzlalı Ekrem Yavuz Duygu Derin Oktar Asoğlu Abdullah İğci Rıdvan İlhan Altan İplikçi |
| author_sort | Yasemin Özlük |
| collection | DOAJ |
| description | AIMS: The aim of this study was to investigate the relationship between Ki- 67 proliferation index and prognosis in primary angiosarcoma of the breast (PAB). Hormonal status of PAB was also discussed, since PAB sometimes can be seen with coexistent pregnancy.METHODS: During a 17-year period 4 cases of PAB were established out of almost 5000 breast biopsies. Immunohistochemical analyzes were performed for antibodies against CD31, CD34, estrogen receptor (ER) and progesterone receptor (PR). Ki-67 proliferation index was also investigated.RESULTS: All patients clinically presented with a palpable mass. The mean patient age at diagnosis was 40.8 years (29-56). Two patients were at the end of their first trimester in pregnancy. The mean score of Ki-67 index was 28.7% (2-55%). Two patients with Grade I tumor and with the lowest Ki-67 index were alive with no evidence of disease 7-8 years after surgery. Proliferation index was detected to be 50% in Grade II tumor, and the patient has been receiving radiotherapy and chemotherapy because of distant metastases. The patient with Grade III tumor died with disseminated disease one year after the initial diagnosis. Positive immunoreactivity for ER and PR could not be detected in any tumor.CONCLUSIONS: Since, it was previously stated that grading is the most important prognostic indicator, we suggest that Ki-67 proliferation index may also be used for the same purpose. No evidence of an association with hormonal status could be drawn. |
| first_indexed | 2024-04-10T11:07:37Z |
| format | Article |
| id | doaj.art-4f7b74530115474ab85e243a70040338 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T11:07:37Z |
| publishDate | 2006-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-4f7b74530115474ab85e243a700403382023-02-15T16:19:21ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312006-07-012312713013049054PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy?Yasemin Özlük0Sıtkı Tuzlalı1Ekrem Yavuz2Duygu Derin3Oktar Asoğlu4Abdullah İğci5Rıdvan İlhan6Altan İplikçi7 İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi Onkoloji Enstitüsü, Tıbbi Onkoloji Bilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi İstanbul Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi İstanbul Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye AIMS: The aim of this study was to investigate the relationship between Ki- 67 proliferation index and prognosis in primary angiosarcoma of the breast (PAB). Hormonal status of PAB was also discussed, since PAB sometimes can be seen with coexistent pregnancy.METHODS: During a 17-year period 4 cases of PAB were established out of almost 5000 breast biopsies. Immunohistochemical analyzes were performed for antibodies against CD31, CD34, estrogen receptor (ER) and progesterone receptor (PR). Ki-67 proliferation index was also investigated.RESULTS: All patients clinically presented with a palpable mass. The mean patient age at diagnosis was 40.8 years (29-56). Two patients were at the end of their first trimester in pregnancy. The mean score of Ki-67 index was 28.7% (2-55%). Two patients with Grade I tumor and with the lowest Ki-67 index were alive with no evidence of disease 7-8 years after surgery. Proliferation index was detected to be 50% in Grade II tumor, and the patient has been receiving radiotherapy and chemotherapy because of distant metastases. The patient with Grade III tumor died with disseminated disease one year after the initial diagnosis. Positive immunoreactivity for ER and PR could not be detected in any tumor.CONCLUSIONS: Since, it was previously stated that grading is the most important prognostic indicator, we suggest that Ki-67 proliferation index may also be used for the same purpose. No evidence of an association with hormonal status could be drawn. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/prmary-angosarcoma-of-the-breast-s-k-67-proliferat/42717 |
| spellingShingle | Yasemin Özlük Sıtkı Tuzlalı Ekrem Yavuz Duygu Derin Oktar Asoğlu Abdullah İğci Rıdvan İlhan Altan İplikçi PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy? European Journal of Breast Health |
| title | PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy? |
| title_full | PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy? |
| title_fullStr | PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy? |
| title_full_unstemmed | PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy? |
| title_short | PRIMARY ANGIOSARCOMA OF THE BREAST: IS KI-67 proliferation index related to histologic grade? Does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy? |
| title_sort | primary angiosarcoma of the breast is ki 67 proliferation index related to histologic grade does steroid hormone receptor expression play a role in the frequency of coexistent pregnancy |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/prmary-angosarcoma-of-the-breast-s-k-67-proliferat/42717
|
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