A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis
AIM: To investigate and evaluate the effectiveness and safety of tobramycin and dexamethasone ointment in the treatment of blepharitis. <p>METHODS: We searched in Pubmed, Medline, Embase, Elsevier, Cochrane Library, Wangfang database, CNKI, VIP database, Sinomed database, and gray literature w...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-11-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2017/11/201711013.pdf |
| _version_ | 1811234301013917696 |
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| author | Lan Ke Yan-Ning Yang |
| author_facet | Lan Ke Yan-Ning Yang |
| author_sort | Lan Ke |
| collection | DOAJ |
| description | AIM: To investigate and evaluate the effectiveness and safety of tobramycin and dexamethasone ointment in the treatment of blepharitis. <p>METHODS: We searched in Pubmed, Medline, Embase, Elsevier, Cochrane Library, Wangfang database, CNKI, VIP database, Sinomed database, and gray literature were performing manual. The efficiency, intraocular pressure, adverse reactions and extract valid data were evaluated. <p>RESULTS: Totally 8 controlled trials were enrolled, including 970 patients. Compared with control groups, the efficiency and the intraocular pressure in experiment group had a statistically significant increase(<i>RR</i>=1.75, 95%<i>CI</i>=1.29-2.37, <i>P</i>=0.0003; <i>SMD</i>=1.30, 95%<i>CI</i>=0.85-1.75, <i>P</i><0.00001), and there was no statistic difference in adverse reactions(<i>RR</i>=1.64, 95%<i>CI</i>=0.86-3.10, <i>P</i>=0.13). <p>CONCLUSION: Tobramycin and dexamethasone ointment in treatment of blepharitis is effective with no adverse effects. Due to the quality of the literature is low, there is still need high quality randomized controlled trials. |
| first_indexed | 2024-04-12T11:34:13Z |
| format | Article |
| id | doaj.art-4f7c4a70232e4e04804d89da345f4b5f |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-04-12T11:34:13Z |
| publishDate | 2017-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-4f7c4a70232e4e04804d89da345f4b5f2022-12-22T03:34:53ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-11-0117112045204910.3980/j.issn.1672-5123.2017.11.13A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitisLan Ke0Yan-Ning Yang1Department of Ophthalmology,Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaDepartment of Ophthalmology,Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaAIM: To investigate and evaluate the effectiveness and safety of tobramycin and dexamethasone ointment in the treatment of blepharitis. <p>METHODS: We searched in Pubmed, Medline, Embase, Elsevier, Cochrane Library, Wangfang database, CNKI, VIP database, Sinomed database, and gray literature were performing manual. The efficiency, intraocular pressure, adverse reactions and extract valid data were evaluated. <p>RESULTS: Totally 8 controlled trials were enrolled, including 970 patients. Compared with control groups, the efficiency and the intraocular pressure in experiment group had a statistically significant increase(<i>RR</i>=1.75, 95%<i>CI</i>=1.29-2.37, <i>P</i>=0.0003; <i>SMD</i>=1.30, 95%<i>CI</i>=0.85-1.75, <i>P</i><0.00001), and there was no statistic difference in adverse reactions(<i>RR</i>=1.64, 95%<i>CI</i>=0.86-3.10, <i>P</i>=0.13). <p>CONCLUSION: Tobramycin and dexamethasone ointment in treatment of blepharitis is effective with no adverse effects. Due to the quality of the literature is low, there is still need high quality randomized controlled trials.http://ies.ijo.cn/cn_publish/2017/11/201711013.pdftreatment of blepharitistobramycin and dexamethasone ointmentmeta-analysisrandomized controlled trialsrandomized controlled trials |
| spellingShingle | Lan Ke Yan-Ning Yang A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis Guoji Yanke Zazhi treatment of blepharitis tobramycin and dexamethasone ointment meta-analysis randomized controlled trials randomized controlled trials |
| title | A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis |
| title_full | A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis |
| title_fullStr | A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis |
| title_full_unstemmed | A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis |
| title_short | A meta-analysis of tobramycin and dexamethasone ointment in treatment of blepharitis |
| title_sort | meta analysis of tobramycin and dexamethasone ointment in treatment of blepharitis |
| topic | treatment of blepharitis tobramycin and dexamethasone ointment meta-analysis randomized controlled trials randomized controlled trials |
| url | http://ies.ijo.cn/cn_publish/2017/11/201711013.pdf |
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