Tenofovir vaginal film as a potential MPT product against HIV-1 and HSV-2 acquisition: formulation development and preclinical assessment in non-human primates

Tenofovir vaginal film as a potential MPT product against HIV-1 and HSV-2 acquisition: formulation development and preclinical assessment in non-human primates

Tenofovir (TFV) is an adenosine nucleotide analog with activity against HIV and HSV-2. Secondary analyses of clinical trials evaluating TFV gel as pre-exposure prophylaxis (PrEP) for HIV have shown that gel formulations of TFV provide significant protection against both HIV and HSV-2 acquisition in...

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Bibliographic Details
Main Authors: Sravan Kumar Patel, Hrushikesh Agashe, Dorothy L. Patton, Yvonne Sweeney, May A. Beamer, Craig W. Hendrix, Sharon L. Hillier, Lisa C. Rohan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Reproductive Health
Subjects:
HIV prevention
genital herpes
multipurpose technology
tenofovir
vaginal film
women health
Online Access:https://www.frontiersin.org/articles/10.3389/frph.2023.1217835/full

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