Development of a 3D printed surgical guide for Brugada syndrome substrate ablation
BackgroundBrugada syndrome (BrS) is a disease associated with ventricular arrhythmias and sudden cardiac death. Epicardial ablation has demonstrated high therapeutic efficacy in preventing ventricular arrhythmias. The purpose of this research is to define a workflow to create a patient-specific 3D-p...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1029685/full |
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| author | Giacomo Talevi Luigi Pannone Cinzia Monaco Edoardo Bori Ida Anna Cappello Mara Candelari Robbert Ramak Mark La Meir Ali Gharaviri Gian Battista Chierchia Bernardo Innocenti Carlo de Asmundis |
| author_facet | Giacomo Talevi Luigi Pannone Cinzia Monaco Edoardo Bori Ida Anna Cappello Mara Candelari Robbert Ramak Mark La Meir Ali Gharaviri Gian Battista Chierchia Bernardo Innocenti Carlo de Asmundis |
| author_sort | Giacomo Talevi |
| collection | DOAJ |
| description | BackgroundBrugada syndrome (BrS) is a disease associated with ventricular arrhythmias and sudden cardiac death. Epicardial ablation has demonstrated high therapeutic efficacy in preventing ventricular arrhythmias. The purpose of this research is to define a workflow to create a patient-specific 3D-printed tool to be used as a surgical guide for epicardial ablation in BrS.MethodsDue to their mechanical properties and biocompatibility, the MED625FLX and TPU95A were used for cardiac 3D surgical guide printing. ECG imaging was used to define the target region on the right ventricular outflow tract (RVOT). CT scan imaging was used to design the model based on patient anatomy. A 3D patient-specific heart phantom was also printed for fitting test. Sterilization test was finally performed.Results3D printed surgical models with both TPU95A and MED625FLX models were in agreement with pre-specified imputed measurements. The phantom test showed retention of shape and correct fitting of the surgical tool to the reproduced phantom anatomy, as expected, for both materials. The surgical guide adapted to both the RVOT and the left anterior descending artery. Two of the 3D models produced in MED265FLX showed damage due to the sterilization process.ConclusionsA 3D printed patient-specific surgical guide for epicardial substrate ablation in BrS is feasible if a specific workflow is followed. The design of the 3D surgical guide ensures proper fitting on the heart phantom with good stability. Further investigations for clinical use are eagerly awaited. |
| first_indexed | 2024-04-12T07:49:54Z |
| format | Article |
| id | doaj.art-4f80b699b9e942d0b98fe080aee2a83d |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T07:49:54Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-4f80b699b9e942d0b98fe080aee2a83d2022-12-22T03:41:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10296851029685Development of a 3D printed surgical guide for Brugada syndrome substrate ablationGiacomo Talevi0Luigi Pannone1Cinzia Monaco2Edoardo Bori3Ida Anna Cappello4Mara Candelari5Robbert Ramak6Mark La Meir7Ali Gharaviri8Gian Battista Chierchia9Bernardo Innocenti10Carlo de Asmundis11Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumBEAMS Department (Bio Electro and Mechanical Systems), Université Libre de Bruxelles, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumCardiac Surgery Department, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumBEAMS Department (Bio Electro and Mechanical Systems), Université Libre de Bruxelles, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, BelgiumBackgroundBrugada syndrome (BrS) is a disease associated with ventricular arrhythmias and sudden cardiac death. Epicardial ablation has demonstrated high therapeutic efficacy in preventing ventricular arrhythmias. The purpose of this research is to define a workflow to create a patient-specific 3D-printed tool to be used as a surgical guide for epicardial ablation in BrS.MethodsDue to their mechanical properties and biocompatibility, the MED625FLX and TPU95A were used for cardiac 3D surgical guide printing. ECG imaging was used to define the target region on the right ventricular outflow tract (RVOT). CT scan imaging was used to design the model based on patient anatomy. A 3D patient-specific heart phantom was also printed for fitting test. Sterilization test was finally performed.Results3D printed surgical models with both TPU95A and MED625FLX models were in agreement with pre-specified imputed measurements. The phantom test showed retention of shape and correct fitting of the surgical tool to the reproduced phantom anatomy, as expected, for both materials. The surgical guide adapted to both the RVOT and the left anterior descending artery. Two of the 3D models produced in MED265FLX showed damage due to the sterilization process.ConclusionsA 3D printed patient-specific surgical guide for epicardial substrate ablation in BrS is feasible if a specific workflow is followed. The design of the 3D surgical guide ensures proper fitting on the heart phantom with good stability. Further investigations for clinical use are eagerly awaited.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1029685/fullarrhythmias treatment3D printingimage processingsegmentationBrugada syndrome |
| spellingShingle | Giacomo Talevi Luigi Pannone Cinzia Monaco Edoardo Bori Ida Anna Cappello Mara Candelari Robbert Ramak Mark La Meir Ali Gharaviri Gian Battista Chierchia Bernardo Innocenti Carlo de Asmundis Development of a 3D printed surgical guide for Brugada syndrome substrate ablation Frontiers in Cardiovascular Medicine arrhythmias treatment 3D printing image processing segmentation Brugada syndrome |
| title | Development of a 3D printed surgical guide for Brugada syndrome substrate ablation |
| title_full | Development of a 3D printed surgical guide for Brugada syndrome substrate ablation |
| title_fullStr | Development of a 3D printed surgical guide for Brugada syndrome substrate ablation |
| title_full_unstemmed | Development of a 3D printed surgical guide for Brugada syndrome substrate ablation |
| title_short | Development of a 3D printed surgical guide for Brugada syndrome substrate ablation |
| title_sort | development of a 3d printed surgical guide for brugada syndrome substrate ablation |
| topic | arrhythmias treatment 3D printing image processing segmentation Brugada syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1029685/full |
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