Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors
A series of hydrazones, 2-cyano-N'-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide (1), N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-3-chlorobenzohydrazide monohydrate (2·H2O), N'-(2-hydroxy-3-methylbenzylidene)-4-nitrobenzohydrazide (3), and N'-(2-hydroxy-3-trifluoromethoxybe...
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2022-06-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/7252 |
| _version_ | 1797962862050672640 |
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| author | Ling-Wei Xue Shi-Tong Li Yong-Jun Han Xiao-Qiang Luo |
| author_facet | Ling-Wei Xue Shi-Tong Li Yong-Jun Han Xiao-Qiang Luo |
| author_sort | Ling-Wei Xue |
| collection | DOAJ |
| description | A series of hydrazones, 2-cyano-N'-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide (1), N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-3-chlorobenzohydrazide monohydrate (2·H2O), N'-(2-hydroxy-3-methylbenzylidene)-4-nitrobenzohydrazide (3), and N'-(2-hydroxy-3-trifluoromethoxybenzylidene)-4-nitrobenzohydrazide (4), were prepared and structurally characterized by elemental analysis, IR and 1H NMR spectra, and single crystal X-ray determination. Xanthine oxidase inhibitory activities of the compounds were studied. Among the compounds, 2-cyano-N’-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide shows the most effective activity. Docking simulation was performed to insert the compounds into the crystal structure of xanthine oxidase at the active site to investigate the probable binding modes. |
| first_indexed | 2024-04-11T01:20:25Z |
| format | Article |
| id | doaj.art-4f82800336d747529e40d772e1c8f43a |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-04-11T01:20:25Z |
| publishDate | 2022-06-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-4f82800336d747529e40d772e1c8f43a2023-01-03T11:28:42ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552022-06-0169238539210.17344/acsi.2021.72521079Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase InhibitorsLing-Wei Xue0Shi-Tong Li1Yong-Jun Han2Xiao-Qiang Luo3Pingdingshan UniversityThe University of ManchesterPingdingshan UniversityPingdingshan UniversityA series of hydrazones, 2-cyano-N'-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide (1), N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-3-chlorobenzohydrazide monohydrate (2·H2O), N'-(2-hydroxy-3-methylbenzylidene)-4-nitrobenzohydrazide (3), and N'-(2-hydroxy-3-trifluoromethoxybenzylidene)-4-nitrobenzohydrazide (4), were prepared and structurally characterized by elemental analysis, IR and 1H NMR spectra, and single crystal X-ray determination. Xanthine oxidase inhibitory activities of the compounds were studied. Among the compounds, 2-cyano-N’-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide shows the most effective activity. Docking simulation was performed to insert the compounds into the crystal structure of xanthine oxidase at the active site to investigate the probable binding modes.https://journals.matheo.si/index.php/ACSi/article/view/7252hydrazonexanthine oxidaseinhibitioncrystal structuremolecular docking study. |
| spellingShingle | Ling-Wei Xue Shi-Tong Li Yong-Jun Han Xiao-Qiang Luo Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors Acta Chimica Slovenica hydrazone xanthine oxidase inhibition crystal structure molecular docking study. |
| title | Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors |
| title_full | Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors |
| title_fullStr | Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors |
| title_full_unstemmed | Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors |
| title_short | Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors |
| title_sort | synthesis biological evaluation and molecular docking studies of hydrazones as novel xanthine oxidase inhibitors |
| topic | hydrazone xanthine oxidase inhibition crystal structure molecular docking study. |
| url | https://journals.matheo.si/index.php/ACSi/article/view/7252 |
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