Regulation of mRNA Stability During Bacterial Stress Responses
Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their transcriptional and posttranscriptional machinery as a response. Under conditions that cause growth to slow or stop, bacteria typically stabilize their transcriptomes in what has been shown to be a conserved...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.02111/full |
| _version_ | 1818435862497591296 |
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| author | Diego A. Vargas-Blanco Scarlet S. Shell Scarlet S. Shell |
| author_facet | Diego A. Vargas-Blanco Scarlet S. Shell Scarlet S. Shell |
| author_sort | Diego A. Vargas-Blanco |
| collection | DOAJ |
| description | Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their transcriptional and posttranscriptional machinery as a response. Under conditions that cause growth to slow or stop, bacteria typically stabilize their transcriptomes in what has been shown to be a conserved stress response. In recent years, diverse studies have elucidated many of the mechanisms underlying mRNA degradation, yet an understanding of the regulation of mRNA degradation under stress conditions remains elusive. In this review we discuss the diverse mechanisms that have been shown to affect mRNA stability in bacteria. While many of these mechanisms are transcript-specific, they provide insight into possible mechanisms of global mRNA stabilization. To that end, we have compiled information on how mRNA fate is affected by RNA secondary structures; interaction with ribosomes, RNA binding proteins, and small RNAs; RNA base modifications; the chemical nature of 5′ ends; activity and concentration of RNases and other degradation proteins; mRNA and RNase localization; and the stringent response. We also provide an analysis of reported relationships between mRNA abundance and mRNA stability, and discuss the importance of stress-associated mRNA stabilization as a potential target for therapeutic development. |
| first_indexed | 2024-12-14T16:59:38Z |
| format | Article |
| id | doaj.art-4f8419f41d9d48f993ce77353b42630c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T16:59:38Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-4f8419f41d9d48f993ce77353b42630c2022-12-21T22:53:53ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-09-011110.3389/fmicb.2020.02111566724Regulation of mRNA Stability During Bacterial Stress ResponsesDiego A. Vargas-Blanco0Scarlet S. Shell1Scarlet S. Shell2Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, United StatesDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, United StatesProgram in Bioinformatics and Computational Biology, Worcester Polytechnic Institute, Worcester, MA, United StatesBacteria have a remarkable ability to sense environmental changes, swiftly regulating their transcriptional and posttranscriptional machinery as a response. Under conditions that cause growth to slow or stop, bacteria typically stabilize their transcriptomes in what has been shown to be a conserved stress response. In recent years, diverse studies have elucidated many of the mechanisms underlying mRNA degradation, yet an understanding of the regulation of mRNA degradation under stress conditions remains elusive. In this review we discuss the diverse mechanisms that have been shown to affect mRNA stability in bacteria. While many of these mechanisms are transcript-specific, they provide insight into possible mechanisms of global mRNA stabilization. To that end, we have compiled information on how mRNA fate is affected by RNA secondary structures; interaction with ribosomes, RNA binding proteins, and small RNAs; RNA base modifications; the chemical nature of 5′ ends; activity and concentration of RNases and other degradation proteins; mRNA and RNase localization; and the stringent response. We also provide an analysis of reported relationships between mRNA abundance and mRNA stability, and discuss the importance of stress-associated mRNA stabilization as a potential target for therapeutic development.https://www.frontiersin.org/article/10.3389/fmicb.2020.02111/fullribonucleic acidstress responsecarbon starvationnutrient starvationhypoxiamRNA degradation |
| spellingShingle | Diego A. Vargas-Blanco Scarlet S. Shell Scarlet S. Shell Regulation of mRNA Stability During Bacterial Stress Responses Frontiers in Microbiology ribonucleic acid stress response carbon starvation nutrient starvation hypoxia mRNA degradation |
| title | Regulation of mRNA Stability During Bacterial Stress Responses |
| title_full | Regulation of mRNA Stability During Bacterial Stress Responses |
| title_fullStr | Regulation of mRNA Stability During Bacterial Stress Responses |
| title_full_unstemmed | Regulation of mRNA Stability During Bacterial Stress Responses |
| title_short | Regulation of mRNA Stability During Bacterial Stress Responses |
| title_sort | regulation of mrna stability during bacterial stress responses |
| topic | ribonucleic acid stress response carbon starvation nutrient starvation hypoxia mRNA degradation |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2020.02111/full |
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