Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/22/5272 |
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| author | Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Talida Georgiana Cut Cristian Oancea Silvius Alexandru Pescariu Gheorghe Nicusor Pop |
| author_facet | Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Talida Georgiana Cut Cristian Oancea Silvius Alexandru Pescariu Gheorghe Nicusor Pop |
| author_sort | Cristina Tudoran |
| collection | DOAJ |
| description | (1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 and 6 months after the acute COVID-19 infection and investigate if there are differences regarding its evolution between the patients from the first three waves of this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), the 3 and 6 months’ evolution of the echocardiographically estimated systolic pulmonary artery pressures (esPAP) in 116 patients already diagnosed with PH or BPH due to COVID-19 during the first three subsequent waves of COVID-19. (3) Results: We documented a gradual, statistically significant reduction in esPAP values, but also an improvement of the parameters characterizing RVD after 3 and 6 months (<i>p</i> < 0.001). This evolution was somewhat different between subjects infected with different viral strains and was related to the initial severity of the pulmonary injury and PH (adjusted R<sup>2</sup> = 0.722, <i>p</i> < 0.001). (4) Conclusions: PH and RVD alleviate gradually during the recovery after COVID-19, but in some cases, they persist, suggesting the activation of pathophysiological mechanisms responsible for the self-propagation of PH. |
| first_indexed | 2024-03-10T05:23:35Z |
| format | Article |
| id | doaj.art-4f8423a4de4740b88e23f6882b4e317e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:23:35Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4f8423a4de4740b88e23f6882b4e317e2023-11-22T23:48:56ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011022527210.3390/jcm10225272Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 InfectionCristina Tudoran0Mariana Tudoran1Voichita Elena Lazureanu2Adelina Raluca Marinescu3Talida Georgiana Cut4Cristian Oancea5Silvius Alexandru Pescariu6Gheorghe Nicusor Pop7Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VI, Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VI, Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 and 6 months after the acute COVID-19 infection and investigate if there are differences regarding its evolution between the patients from the first three waves of this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), the 3 and 6 months’ evolution of the echocardiographically estimated systolic pulmonary artery pressures (esPAP) in 116 patients already diagnosed with PH or BPH due to COVID-19 during the first three subsequent waves of COVID-19. (3) Results: We documented a gradual, statistically significant reduction in esPAP values, but also an improvement of the parameters characterizing RVD after 3 and 6 months (<i>p</i> < 0.001). This evolution was somewhat different between subjects infected with different viral strains and was related to the initial severity of the pulmonary injury and PH (adjusted R<sup>2</sup> = 0.722, <i>p</i> < 0.001). (4) Conclusions: PH and RVD alleviate gradually during the recovery after COVID-19, but in some cases, they persist, suggesting the activation of pathophysiological mechanisms responsible for the self-propagation of PH.https://www.mdpi.com/2077-0383/10/22/5272pulmonary hypertensionright ventricular dysfunctiontransthoracic echocardiographypost-COVID-19 syndromelong-term evolution |
| spellingShingle | Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Talida Georgiana Cut Cristian Oancea Silvius Alexandru Pescariu Gheorghe Nicusor Pop Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection Journal of Clinical Medicine pulmonary hypertension right ventricular dysfunction transthoracic echocardiography post-COVID-19 syndrome long-term evolution |
| title | Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection |
| title_full | Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection |
| title_fullStr | Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection |
| title_full_unstemmed | Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection |
| title_short | Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection |
| title_sort | factors influencing the evolution of pulmonary hypertension in previously healthy subjects recovering from a sars cov 2 infection |
| topic | pulmonary hypertension right ventricular dysfunction transthoracic echocardiography post-COVID-19 syndrome long-term evolution |
| url | https://www.mdpi.com/2077-0383/10/22/5272 |
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