Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein

Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein

Abstract Periodontal ligament stem cells (PDLSCs) are important mesenchymal stem cells contributing to regenerating lost periodontal tissues and repairing bone defects. Studies on the molecular mechanism affecting the osteogenic differentiation of PDLSCs are necessary. Scopolamine (SCO) is known as...

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Bibliographic Details
Main Authors: Ying Wu, Pan Gong
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Pharmacology Research & Perspectives
Subjects:
lactylation
osteogenic differentiation
PDLSC
RUNX2
scopolamine
Online Access:https://doi.org/10.1002/prp2.1169

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