Role of sigma-1 receptors in neurodegenerative diseases
Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861314000267 |
| _version_ | 1811262963488653312 |
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| author | Linda Nguyen Brandon P. Lucke-Wold Shona A. Mookerjee John Z. Cavendish Matthew J. Robson Anna L. Scandinaro Rae R. Matsumoto |
| author_facet | Linda Nguyen Brandon P. Lucke-Wold Shona A. Mookerjee John Z. Cavendish Matthew J. Robson Anna L. Scandinaro Rae R. Matsumoto |
| author_sort | Linda Nguyen |
| collection | DOAJ |
| description | Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and astrocytes, play an increasingly recognized role in both the promotion and prevention of neurodegeneration. Sigma receptors, particularly the sigma-1 receptor subtype, which are expressed in both neurons and glia of multiple regions within the central nervous system, are a unique class of intracellular proteins that can modulate many biological mechanisms associated with neurodegeneration. These receptors therefore represent compelling putative targets for pharmacologically treating neurodegenerative disorders. In this review, we provide an overview of the biological mechanisms frequently associated with neurodegeneration, and discuss how sigma-1 receptors may alter these mechanisms to preserve or restore neuronal function. In addition, we speculate on their therapeutic potential in the treatment of various neurodegenerative disorders. |
| first_indexed | 2024-04-12T19:36:19Z |
| format | Article |
| id | doaj.art-4f84903b135b42099e22b8d3b7018722 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-12T19:36:19Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-4f84903b135b42099e22b8d3b70187222022-12-22T03:19:12ZengElsevierJournal of Pharmacological Sciences1347-86132015-01-011271172910.1016/j.jphs.2014.12.005Role of sigma-1 receptors in neurodegenerative diseasesLinda Nguyen0Brandon P. Lucke-Wold1Shona A. Mookerjee2John Z. Cavendish3Matthew J. Robson4Anna L. Scandinaro5Rae R. Matsumoto6Department of Basic Pharmaceutical Sciences, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV 26506, United StatesGraduate Program in Neuroscience, West Virginia University, School of Medicine, One Medical Center Drive, Morgantown, WV 26506, United StatesDepartment of Biological and Pharmaceutical Sciences, Touro University California, College of Pharmacy, 1310 Club Drive, Vallejo, CA 94592, United StatesGraduate Program in Neuroscience, West Virginia University, School of Medicine, One Medical Center Drive, Morgantown, WV 26506, United StatesDepartment of Pharmacology, Vanderbilt University School of Medicine, 465 21st Ave, Nashville, TN 37232, United StatesDepartment of Basic Pharmaceutical Sciences, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV 26506, United StatesDepartment of Basic Pharmaceutical Sciences, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV 26506, United StatesNeurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and astrocytes, play an increasingly recognized role in both the promotion and prevention of neurodegeneration. Sigma receptors, particularly the sigma-1 receptor subtype, which are expressed in both neurons and glia of multiple regions within the central nervous system, are a unique class of intracellular proteins that can modulate many biological mechanisms associated with neurodegeneration. These receptors therefore represent compelling putative targets for pharmacologically treating neurodegenerative disorders. In this review, we provide an overview of the biological mechanisms frequently associated with neurodegeneration, and discuss how sigma-1 receptors may alter these mechanisms to preserve or restore neuronal function. In addition, we speculate on their therapeutic potential in the treatment of various neurodegenerative disorders.http://www.sciencedirect.com/science/article/pii/S1347861314000267Sigma-1 receptorsNeuroprotectionNeurodegenerationNeurotoxicityReactive gliosis |
| spellingShingle | Linda Nguyen Brandon P. Lucke-Wold Shona A. Mookerjee John Z. Cavendish Matthew J. Robson Anna L. Scandinaro Rae R. Matsumoto Role of sigma-1 receptors in neurodegenerative diseases Journal of Pharmacological Sciences Sigma-1 receptors Neuroprotection Neurodegeneration Neurotoxicity Reactive gliosis |
| title | Role of sigma-1 receptors in neurodegenerative diseases |
| title_full | Role of sigma-1 receptors in neurodegenerative diseases |
| title_fullStr | Role of sigma-1 receptors in neurodegenerative diseases |
| title_full_unstemmed | Role of sigma-1 receptors in neurodegenerative diseases |
| title_short | Role of sigma-1 receptors in neurodegenerative diseases |
| title_sort | role of sigma 1 receptors in neurodegenerative diseases |
| topic | Sigma-1 receptors Neuroprotection Neurodegeneration Neurotoxicity Reactive gliosis |
| url | http://www.sciencedirect.com/science/article/pii/S1347861314000267 |
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