Role of sigma-1 receptors in neurodegenerative diseases

Role of sigma-1 receptors in neurodegenerative diseases

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and...

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Bibliographic Details
Main Authors: Linda Nguyen, Brandon P. Lucke-Wold, Shona A. Mookerjee, John Z. Cavendish, Matthew J. Robson, Anna L. Scandinaro, Rae R. Matsumoto
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Sigma-1 receptors
Neuroprotection
Neurodegeneration
Neurotoxicity
Reactive gliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000267

Internet

http://www.sciencedirect.com/science/article/pii/S1347861314000267

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