Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
ObjectivesAdequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative wome...
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| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.884851/full |
| _version_ | 1811332761723600896 |
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| author | Qingru Wang Yangqian Jiang Yangqian Jiang Hong Lv Hong Lv Hong Lv Qun Lu Qun Lu Shiyao Tao Shiyao Tao Rui Qin Rui Qin Lei Huang Lei Huang Cong Liu Cong Liu Xin Xu Xin Xu Siyuan Lv Siyuan Lv Mei Li Mei Li Zhi Li Zhi Li Jiangbo Du Jiangbo Du Jiangbo Du Yuan Lin Yuan Lin Yuan Lin Hongxia Ma Hongxia Ma Hongxia Ma Xia Chi Zhibin Hu Zhibin Hu Zhibin Hu Tao Jiang Guoying Zhang Guoying Zhang |
| author_facet | Qingru Wang Yangqian Jiang Yangqian Jiang Hong Lv Hong Lv Hong Lv Qun Lu Qun Lu Shiyao Tao Shiyao Tao Rui Qin Rui Qin Lei Huang Lei Huang Cong Liu Cong Liu Xin Xu Xin Xu Siyuan Lv Siyuan Lv Mei Li Mei Li Zhi Li Zhi Li Jiangbo Du Jiangbo Du Jiangbo Du Yuan Lin Yuan Lin Yuan Lin Hongxia Ma Hongxia Ma Hongxia Ma Xia Chi Zhibin Hu Zhibin Hu Zhibin Hu Tao Jiang Guoying Zhang Guoying Zhang |
| author_sort | Qingru Wang |
| collection | DOAJ |
| description | ObjectivesAdequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative women.MethodsThe present study was conducted within the Jiangsu Birth Cohort. A total of 793 mother–infant pairs were eligible for the present study. Maternal thyroid function was assessed by measuring serum thyroid-stimulating hormone, free thyroxine, and thyroid peroxidase antibodies. Neurodevelopment of infants was assessed by using the Bayley Scales of Infant and Toddler Development third edition screening test (Bayley-III screening test).ResultsIn the multivariate adjusted linear regression analyses, infants of women with subclinical hypothyroidism and isolated hypothyroxinemia were associated with decreased receptive communication scores (β = −0.68, p = 0.034) and decreased gross motor scores (β = −0.83, p = 0.008), respectively. Moreover, infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L) and low FT4 concentrations were significantly associated with lower gross motor scores (β = −1.19, p = 0.032), while no differences were observed in infants when the mothers had a high-normal TSH concentration and normal FT4 levels.ConclusionsMaternal subclinical hypothyroidism is associated with decreased receptive communication scores in infants at 1 year of age. In addition, maternal TSH concentration greater than 4.0 mIU/L and maternal isolated hypothyroxinemia are associated with impaired gross motor ability of infants, especially in infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L). |
| first_indexed | 2024-04-13T16:41:51Z |
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| id | doaj.art-4f87267d32b34e26a647d4fbc6696ac9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T16:41:51Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4f87267d32b34e26a647d4fbc6696ac92022-12-22T02:39:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-06-011310.3389/fendo.2022.884851884851Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort StudyQingru Wang0Yangqian Jiang1Yangqian Jiang2Hong Lv3Hong Lv4Hong Lv5Qun Lu6Qun Lu7Shiyao Tao8Shiyao Tao9Rui Qin10Rui Qin11Lei Huang12Lei Huang13Cong Liu14Cong Liu15Xin Xu16Xin Xu17Siyuan Lv18Siyuan Lv19Mei Li20Mei Li21Zhi Li22Zhi Li23Jiangbo Du24Jiangbo Du25Jiangbo Du26Yuan Lin27Yuan Lin28Yuan Lin29Hongxia Ma30Hongxia Ma31Hongxia Ma32Xia Chi33Zhibin Hu34Zhibin Hu35Zhibin Hu36Tao Jiang37Guoying Zhang38Guoying Zhang39State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Toxicology and Nutritional Science, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaKey Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaKey Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Child Health Care, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, ChinaObjectivesAdequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative women.MethodsThe present study was conducted within the Jiangsu Birth Cohort. A total of 793 mother–infant pairs were eligible for the present study. Maternal thyroid function was assessed by measuring serum thyroid-stimulating hormone, free thyroxine, and thyroid peroxidase antibodies. Neurodevelopment of infants was assessed by using the Bayley Scales of Infant and Toddler Development third edition screening test (Bayley-III screening test).ResultsIn the multivariate adjusted linear regression analyses, infants of women with subclinical hypothyroidism and isolated hypothyroxinemia were associated with decreased receptive communication scores (β = −0.68, p = 0.034) and decreased gross motor scores (β = −0.83, p = 0.008), respectively. Moreover, infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L) and low FT4 concentrations were significantly associated with lower gross motor scores (β = −1.19, p = 0.032), while no differences were observed in infants when the mothers had a high-normal TSH concentration and normal FT4 levels.ConclusionsMaternal subclinical hypothyroidism is associated with decreased receptive communication scores in infants at 1 year of age. In addition, maternal TSH concentration greater than 4.0 mIU/L and maternal isolated hypothyroxinemia are associated with impaired gross motor ability of infants, especially in infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L).https://www.frontiersin.org/articles/10.3389/fendo.2022.884851/fullthyroid hypofunctionpregnancyneurodevelopmentinfancycohort study |
| spellingShingle | Qingru Wang Yangqian Jiang Yangqian Jiang Hong Lv Hong Lv Hong Lv Qun Lu Qun Lu Shiyao Tao Shiyao Tao Rui Qin Rui Qin Lei Huang Lei Huang Cong Liu Cong Liu Xin Xu Xin Xu Siyuan Lv Siyuan Lv Mei Li Mei Li Zhi Li Zhi Li Jiangbo Du Jiangbo Du Jiangbo Du Yuan Lin Yuan Lin Yuan Lin Hongxia Ma Hongxia Ma Hongxia Ma Xia Chi Zhibin Hu Zhibin Hu Zhibin Hu Tao Jiang Guoying Zhang Guoying Zhang Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study Frontiers in Endocrinology thyroid hypofunction pregnancy neurodevelopment infancy cohort study |
| title | Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study |
| title_full | Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study |
| title_fullStr | Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study |
| title_full_unstemmed | Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study |
| title_short | Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study |
| title_sort | association of maternal mild hypothyroidism with offspring neurodevelopment in tpoab negative women a prospective cohort study |
| topic | thyroid hypofunction pregnancy neurodevelopment infancy cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.884851/full |
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