Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treat...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/4988 |
| _version_ | 1797512281055035392 |
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| author | Ana-Belen Ariza-Jimenez Isabel Leiva Gea Maria Jose Martinez-Aedo Ollero Juan Pedro Lopez-Siguero |
| author_facet | Ana-Belen Ariza-Jimenez Isabel Leiva Gea Maria Jose Martinez-Aedo Ollero Juan Pedro Lopez-Siguero |
| author_sort | Ana-Belen Ariza-Jimenez |
| collection | DOAJ |
| description | Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects. Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were −1.52 SD, −1.31 SD, and −2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD. Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups. |
| first_indexed | 2024-03-10T05:59:39Z |
| format | Article |
| id | doaj.art-4f881e7366af45fcbb92a7450b616b30 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:59:39Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4f881e7366af45fcbb92a7450b616b302023-11-22T21:05:40ZengMDPI AGJournal of Clinical Medicine2077-03832021-10-011021498810.3390/jcm10214988Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult HeightAna-Belen Ariza-Jimenez0Isabel Leiva Gea1Maria Jose Martinez-Aedo Ollero2Juan Pedro Lopez-Siguero3Pediatric Endocrinology, Hospital Regional Universitario de Málaga, 29010 Málaga, SpainPediatric Endocrinology, Hospital Regional Universitario de Málaga, 29010 Málaga, SpainPediatric Endocrinology, Hospital Regional Universitario de Málaga, 29010 Málaga, SpainPediatric Endocrinology, Hospital Regional Universitario de Málaga, 29010 Málaga, SpainIntroduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects. Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were −1.52 SD, −1.31 SD, and −2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD. Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups.https://www.mdpi.com/2077-0383/10/21/4988growth hormone treatmentgrowth hormone deficiencyidiopathic short staturefinal height |
| spellingShingle | Ana-Belen Ariza-Jimenez Isabel Leiva Gea Maria Jose Martinez-Aedo Ollero Juan Pedro Lopez-Siguero Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height Journal of Clinical Medicine growth hormone treatment growth hormone deficiency idiopathic short stature final height |
| title | Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height |
| title_full | Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height |
| title_fullStr | Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height |
| title_full_unstemmed | Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height |
| title_short | Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height |
| title_sort | isolated growth hormone deficiency and idiopathic short stature comparative efficiency after growth hormone treatment up to adult height |
| topic | growth hormone treatment growth hormone deficiency idiopathic short stature final height |
| url | https://www.mdpi.com/2077-0383/10/21/4988 |
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