In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine
Prostate cancer (PCa) is a prevalent malignancy affecting men worldwide. Animal models play crucial role in studying PCa pathology and discover novel approaches to prevent, detect and treat this disease. However, the challenge of translational medicine is the limited reproducibility and inadequate r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2023-06-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/?mno=146247 |
| _version_ | 1827790862232322048 |
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| author | Elisabete Nascimento-Goncalves Fernanda Seixas Rita Ferreira Paula A. Oliveira Bruno Colaco |
| author_facet | Elisabete Nascimento-Goncalves Fernanda Seixas Rita Ferreira Paula A. Oliveira Bruno Colaco |
| author_sort | Elisabete Nascimento-Goncalves |
| collection | DOAJ |
| description | Prostate cancer (PCa) is a prevalent malignancy affecting men worldwide. Animal models play crucial role in studying PCa pathology and discover novel approaches to prevent, detect and treat this disease. However, the challenge of translational medicine is the limited reproducibility and inadequate recapitulation of human conditions in animal models. Therefore, a comprehensive understanding of the macroscopic and microscopic anatomy of prostate gland among distinct animal species is essential for better translating research findings to clinical practice. This review aims to compare and describe the macroscopic and microscopic anatomy of the prostate gland in humans, rats, and dogs, emphasizing the relevant features. Despite the anatomical differences between these species, rats are a valuable model to study human prostate diseases, once they share some features implicated in carcinogenesis in humans. Dogs, on the other hand, are considered the best model for studying prostate cancer due to the development of spontaneous cancer with a higher incidence when compared with other animals and the development of bone metastases. Moreover, the lymphatic system and the sentinel lymph node role and mapping are similar in dogs and humans. However, it is important to recognize that no animal model can directly mimic all aspects of prostate cancer as the human prostate is anatomically different from that of rats and dogs. Therefore, it is essential to analyse and understand the intra- and interspecies variability when translating research findings into clinical practice. This review highlights the importance of a thorough understanding of the anatomical differences between the prostate gland in humans, rats, and dogs when selecting the appropriate animal model for studying prostate cancer. [Open Vet J 2023; 13(6.000): 782-793] |
| first_indexed | 2024-03-11T17:37:44Z |
| format | Article |
| id | doaj.art-4f883816ea39448b9a66d0c5f1692859 |
| institution | Directory Open Access Journal |
| issn | 2226-4485 |
| language | English |
| last_indexed | 2024-03-11T17:37:44Z |
| publishDate | 2023-06-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-4f883816ea39448b9a66d0c5f16928592023-10-18T15:29:29ZengTripoli UniversityOpen Veterinary Journal2226-44852023-06-0113678279310.5455/OVJ.2023.v13.i6.13146247In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicineElisabete Nascimento-Goncalves0Fernanda Seixas1Rita Ferreira2Paula A. Oliveira3Bruno Colaco4Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tras-os-Montes and Alto Douro (UTAD), Vila Real, Portugal Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), UTAD, 5000-801 Vila Real, Portugal LAQV-REQUIMTE, Department of Chemistry University of Aveiro (UA), 3810-193 Aveiro, Portugal LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Science – AL4AnimalS, UTAD, Vila Real, PortugalProstate cancer (PCa) is a prevalent malignancy affecting men worldwide. Animal models play crucial role in studying PCa pathology and discover novel approaches to prevent, detect and treat this disease. However, the challenge of translational medicine is the limited reproducibility and inadequate recapitulation of human conditions in animal models. Therefore, a comprehensive understanding of the macroscopic and microscopic anatomy of prostate gland among distinct animal species is essential for better translating research findings to clinical practice. This review aims to compare and describe the macroscopic and microscopic anatomy of the prostate gland in humans, rats, and dogs, emphasizing the relevant features. Despite the anatomical differences between these species, rats are a valuable model to study human prostate diseases, once they share some features implicated in carcinogenesis in humans. Dogs, on the other hand, are considered the best model for studying prostate cancer due to the development of spontaneous cancer with a higher incidence when compared with other animals and the development of bone metastases. Moreover, the lymphatic system and the sentinel lymph node role and mapping are similar in dogs and humans. However, it is important to recognize that no animal model can directly mimic all aspects of prostate cancer as the human prostate is anatomically different from that of rats and dogs. Therefore, it is essential to analyse and understand the intra- and interspecies variability when translating research findings into clinical practice. This review highlights the importance of a thorough understanding of the anatomical differences between the prostate gland in humans, rats, and dogs when selecting the appropriate animal model for studying prostate cancer. [Open Vet J 2023; 13(6.000): 782-793]https://www.openveterinaryjournal.com/?mno=146247anatomydoghumanprostaterat |
| spellingShingle | Elisabete Nascimento-Goncalves Fernanda Seixas Rita Ferreira Paula A. Oliveira Bruno Colaco In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine Open Veterinary Journal anatomy dog human prostate rat |
| title | In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine |
| title_full | In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine |
| title_fullStr | In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine |
| title_full_unstemmed | In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine |
| title_short | In vivo prostate cancer research: Key interspecies prostate anatomical features for translation medicine |
| title_sort | in vivo prostate cancer research key interspecies prostate anatomical features for translation medicine |
| topic | anatomy dog human prostate rat |
| url | https://www.openveterinaryjournal.com/?mno=146247 |
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