Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations
Gut microbiota plays a crucial role in modulating immune responses, including effector response to infection and surveillance of tumors. This article summarizes the current scientific evidence on the effects of supplementation with prebiotics, probiotics, and synbiotics on high-risk human papillomav...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1383258/full |
| _version_ | 1797238459459436544 |
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| author | Gabriela Gutiérrez Salmeán Gabriela Gutiérrez Salmeán Merari Delgadillo González Ariadna Alejandra Rueda Escalona José Antonio Leyva Islas Denisse Castro-Eguiluz |
| author_facet | Gabriela Gutiérrez Salmeán Gabriela Gutiérrez Salmeán Merari Delgadillo González Ariadna Alejandra Rueda Escalona José Antonio Leyva Islas Denisse Castro-Eguiluz |
| author_sort | Gabriela Gutiérrez Salmeán |
| collection | DOAJ |
| description | Gut microbiota plays a crucial role in modulating immune responses, including effector response to infection and surveillance of tumors. This article summarizes the current scientific evidence on the effects of supplementation with prebiotics, probiotics, and synbiotics on high-risk human papillomavirus (HPV) infections, precancerous lesions, and various stages of cervical cancer development and treatment while also examining the underlying molecular pathways involved. Our findings indicate that a higher dietary fiber intake is associated with a reduced risk of HPV infection, while certain probiotics have shown promising results in clearing HPV-related lesions. Additionally, certain strains of probiotics, prebiotics such as inulin and fructo-oligosaccharides, and synbiotics decrease the frequency of gastrointestinal adverse effects in cervical cancer patients. These agents attain their results by modulating crucial metabolic pathways, including the reduction of inflammation and oxidative stress, promoting apoptosis, inhibiting cell proliferation, and suppressing the activity of oncogenes, thus attenuating tumorigenesis. We conclude that although further human studies are necessary, robust evidence in preclinical models demonstrates that prebiotics, probiotics, and synbiotics play an essential role in cervical cancer, from infection to carcinogenesis and its medical treatment. Consequently, we strongly recommend conducting high-quality clinical trials using these agents as adjuvants since they have proven safe. |
| first_indexed | 2024-04-24T17:35:59Z |
| format | Article |
| id | doaj.art-4f88445f0c664babab8b7615a6bbd371 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T17:35:59Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4f88445f0c664babab8b7615a6bbd3712024-03-28T05:04:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13832581383258Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendationsGabriela Gutiérrez Salmeán0Gabriela Gutiérrez Salmeán1Merari Delgadillo González2Ariadna Alejandra Rueda Escalona3José Antonio Leyva Islas4Denisse Castro-Eguiluz5Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac Mexico, Huixquilucan, Estado de Mexico, MexicoServicio de Nutrición, Centro de Especialidades del Riñón (CER), Naucalpan de Juarez, Estado de Mexico, MexicoModelo Integral para la atención del Cáncer Cervicouterino Localmente Avanzado y Avanzado (MICAELA) Program, Instituto Nacional de Cancerología, Mexico City, MexicoMasters in Medical Sciences Program, Universidad Anáhuac Mexico, Huixquilucan, Estado de Mexico, MexicoNutritional and Metabolic Support, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE) Hospital Regional Lic. Adolfo López Mateos, Mexico City, MexicoInvestigador por México, Consejo Nacional de Humanidades Ciencias y Tecnologías (CONAHCyT)—Department of Clinical Research, Instituto Nacional de Cancerología, Mexico City, MexicoGut microbiota plays a crucial role in modulating immune responses, including effector response to infection and surveillance of tumors. This article summarizes the current scientific evidence on the effects of supplementation with prebiotics, probiotics, and synbiotics on high-risk human papillomavirus (HPV) infections, precancerous lesions, and various stages of cervical cancer development and treatment while also examining the underlying molecular pathways involved. Our findings indicate that a higher dietary fiber intake is associated with a reduced risk of HPV infection, while certain probiotics have shown promising results in clearing HPV-related lesions. Additionally, certain strains of probiotics, prebiotics such as inulin and fructo-oligosaccharides, and synbiotics decrease the frequency of gastrointestinal adverse effects in cervical cancer patients. These agents attain their results by modulating crucial metabolic pathways, including the reduction of inflammation and oxidative stress, promoting apoptosis, inhibiting cell proliferation, and suppressing the activity of oncogenes, thus attenuating tumorigenesis. We conclude that although further human studies are necessary, robust evidence in preclinical models demonstrates that prebiotics, probiotics, and synbiotics play an essential role in cervical cancer, from infection to carcinogenesis and its medical treatment. Consequently, we strongly recommend conducting high-quality clinical trials using these agents as adjuvants since they have proven safe.https://www.frontiersin.org/articles/10.3389/fonc.2024.1383258/fullhuman papillomavirusHPV-infectioncervical cancerchemoradiotherapyprebioticprobiotic |
| spellingShingle | Gabriela Gutiérrez Salmeán Gabriela Gutiérrez Salmeán Merari Delgadillo González Ariadna Alejandra Rueda Escalona José Antonio Leyva Islas Denisse Castro-Eguiluz Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations Frontiers in Oncology human papillomavirus HPV-infection cervical cancer chemoradiotherapy prebiotic probiotic |
| title | Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations |
| title_full | Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations |
| title_fullStr | Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations |
| title_full_unstemmed | Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations |
| title_short | Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations |
| title_sort | effects of prebiotics probiotics and synbiotics on the prevention and treatment of cervical cancer mexican consensus and recommendations |
| topic | human papillomavirus HPV-infection cervical cancer chemoradiotherapy prebiotic probiotic |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1383258/full |
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