Using structural connectivity to augment community structure in EEG functional connectivity
AbstractRecently, EEG recording techniques and source analysis have improved, making it feasible to tap into fast network dynamics. Yet, analyzing whole-cortex EEG signals in source space is not standard, partly because EEG suffers from volume conduction: Functional connectivity (FC) reflecting genu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The MIT Press
2020-08-01
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| Series: | Network Neuroscience |
| Online Access: | https://direct.mit.edu/netn/article/4/3/761/95852/Using-structural-connectivity-to-augment-community |
| _version_ | 1818299246500118528 |
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| author | Katharina Glomb Emeline Mullier Margherita Carboni Maria Rubega Giannarita Iannotti Sebastien Tourbier Martin Seeber Serge Vulliemoz Patric Hagmann |
| author_facet | Katharina Glomb Emeline Mullier Margherita Carboni Maria Rubega Giannarita Iannotti Sebastien Tourbier Martin Seeber Serge Vulliemoz Patric Hagmann |
| author_sort | Katharina Glomb |
| collection | DOAJ |
| description | AbstractRecently, EEG recording techniques and source analysis have improved, making it feasible to tap into fast network dynamics. Yet, analyzing whole-cortex EEG signals in source space is not standard, partly because EEG suffers from volume conduction: Functional connectivity (FC) reflecting genuine functional relationships is impossible to disentangle from spurious FC introduced by volume conduction. Here, we investigate the relationship between white matter structural connectivity (SC) and large-scale network structure encoded in EEG-FC. We start by confirming that FC (power envelope correlations) is predicted by SC beyond the impact of Euclidean distance, in line with the assumption that SC mediates genuine FC. We then use information from white matter structural connectivity in order to smooth the EEG signal in the space spanned by graphs derived from SC. Thereby, FC between nearby, structurally connected brain regions increases while FC between nonconnected regions remains unchanged, resulting in an increase in genuine, SC-mediated FC. We analyze the induced changes in FC, assessing the resemblance between EEG-FC and volume-conduction- free fMRI-FC, and find that smoothing increases resemblance in terms of overall correlation and community structure. This result suggests that our method boosts genuine FC, an outcome that is of interest for many EEG network neuroscience questions. |
| first_indexed | 2024-12-13T04:48:10Z |
| format | Article |
| id | doaj.art-4f8a7fe86094482a90a52343189132b9 |
| institution | Directory Open Access Journal |
| issn | 2472-1751 |
| language | English |
| last_indexed | 2024-12-13T04:48:10Z |
| publishDate | 2020-08-01 |
| publisher | The MIT Press |
| record_format | Article |
| series | Network Neuroscience |
| spelling | doaj.art-4f8a7fe86094482a90a52343189132b92022-12-21T23:59:05ZengThe MIT PressNetwork Neuroscience2472-17512020-08-014376178710.1162/netn_a_00147Using structural connectivity to augment community structure in EEG functional connectivityKatharina Glomb0http://orcid.org/0000-0002-4596-4386Emeline Mullier1Margherita Carboni2Maria Rubega3Giannarita Iannotti4Sebastien Tourbier5Martin Seeber6Serge Vulliemoz7Patric Hagmann8Connectomics Lab, Department of Radiology, University Hospital of Lausanne and University of Lausanne, Lausanne (CHUV-UNIL), Vaud, SwitzerlandConnectomics Lab, Department of Radiology, University Hospital of Lausanne and University of Lausanne, Lausanne (CHUV-UNIL), Vaud, SwitzerlandEEG and Epilepsy, Neurology, University Hospitals of Geneva and University of Geneva, Geneva, SwitzerlandDepartment of Neurosciences, University of Padova, Padova, ItalyFunctional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, SwitzerlandConnectomics Lab, Department of Radiology, University Hospital of Lausanne and University of Lausanne, Lausanne (CHUV-UNIL), Vaud, SwitzerlandFunctional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, SwitzerlandEEG and Epilepsy, Neurology, University Hospitals of Geneva and University of Geneva, Geneva, SwitzerlandConnectomics Lab, Department of Radiology, University Hospital of Lausanne and University of Lausanne, Lausanne (CHUV-UNIL), Vaud, SwitzerlandAbstractRecently, EEG recording techniques and source analysis have improved, making it feasible to tap into fast network dynamics. Yet, analyzing whole-cortex EEG signals in source space is not standard, partly because EEG suffers from volume conduction: Functional connectivity (FC) reflecting genuine functional relationships is impossible to disentangle from spurious FC introduced by volume conduction. Here, we investigate the relationship between white matter structural connectivity (SC) and large-scale network structure encoded in EEG-FC. We start by confirming that FC (power envelope correlations) is predicted by SC beyond the impact of Euclidean distance, in line with the assumption that SC mediates genuine FC. We then use information from white matter structural connectivity in order to smooth the EEG signal in the space spanned by graphs derived from SC. Thereby, FC between nearby, structurally connected brain regions increases while FC between nonconnected regions remains unchanged, resulting in an increase in genuine, SC-mediated FC. We analyze the induced changes in FC, assessing the resemblance between EEG-FC and volume-conduction- free fMRI-FC, and find that smoothing increases resemblance in terms of overall correlation and community structure. This result suggests that our method boosts genuine FC, an outcome that is of interest for many EEG network neuroscience questions.https://direct.mit.edu/netn/article/4/3/761/95852/Using-structural-connectivity-to-augment-community |
| spellingShingle | Katharina Glomb Emeline Mullier Margherita Carboni Maria Rubega Giannarita Iannotti Sebastien Tourbier Martin Seeber Serge Vulliemoz Patric Hagmann Using structural connectivity to augment community structure in EEG functional connectivity Network Neuroscience |
| title | Using structural connectivity to augment community structure in EEG functional connectivity |
| title_full | Using structural connectivity to augment community structure in EEG functional connectivity |
| title_fullStr | Using structural connectivity to augment community structure in EEG functional connectivity |
| title_full_unstemmed | Using structural connectivity to augment community structure in EEG functional connectivity |
| title_short | Using structural connectivity to augment community structure in EEG functional connectivity |
| title_sort | using structural connectivity to augment community structure in eeg functional connectivity |
| url | https://direct.mit.edu/netn/article/4/3/761/95852/Using-structural-connectivity-to-augment-community |
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