Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC

Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promising antitumor activity in preclinical studies. However, the efficacy of recombinant TRAIL in clinical trials is compromised by its short serum half-life and low in vivo stability. Induction of endogenous TRAIL may overcome t...

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Bibliographic Details
Main Authors: Shuang Liu, Erik V. Polsdofer, Lukun Zhou, Sanbao Ruan, Hui Lyu, Defu Hou, Hao Liu, Ann D. Thor, Zhimin He, Bolin Liu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
metformin
TRAIL
apoptosis
TNBC
NSCLC
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000620

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