The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy
Purpose: To describe the longitudinal structural changes of myopic traction maculopathy (MTM) based on optical coherence tomography (OCT) and to detect biomarkers in the evolution of MTM.Methods: A retrospective study was conducted on patients with MTM as defined by OCT. A minimum follow-up of 6 mon...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.802626/full |
| _version_ | 1818974636195446784 |
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| author | Dong Fang Jindi Su Lu Chen Shaochong Zhang |
| author_facet | Dong Fang Jindi Su Lu Chen Shaochong Zhang |
| author_sort | Dong Fang |
| collection | DOAJ |
| description | Purpose: To describe the longitudinal structural changes of myopic traction maculopathy (MTM) based on optical coherence tomography (OCT) and to detect biomarkers in the evolution of MTM.Methods: A retrospective study was conducted on patients with MTM as defined by OCT. A minimum follow-up of 6 months was necessary for study inclusion. The effects of comprehensive OCT-based structure on the evolution of MTM, the progression rates, and resolution rates of MTM were evaluated.Results: A total of 120 eyes (120 patients) were included with an average follow-up of 15.4 months. During the follow-up, MTM progressed in 32 eyes (26.67%). The most common pattern of progression observed was the increased extent of retinoschisis in 12 eyes. The multivariate analysis showed that the presence of MTM progression had a significant correlation with internal limiting membrane (ILM) detachment and retinoschisis involved the entire macula at baseline. Five eyes (4.17%) experienced MTM resolution, of which 2 eyes developed disruptions of detached ILM, two eyes developed disruptions of epiretinal membrane, and one eye developed partial posterior vitreous detachment. Eyes with foveal detachment showed the highest progression rate (41.67%) and highest resolution rate (16.67%) compared to the eyes with other foveal complications.Conclusion: ILM detachment is a risk factor for MTM progression and MTM resolution can occur after ILM disruption. These suggest that ILM may play an important role as a biomarker in the evolution of MTM. |
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| format | Article |
| id | doaj.art-4f8bb82138d54a7fbc5d575a212ca19a |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T15:43:12Z |
| publishDate | 2022-01-01 |
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| spelling | doaj.art-4f8bb82138d54a7fbc5d575a212ca19a2022-12-21T19:35:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.802626802626The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction MaculopathyDong Fang0Jindi Su1Lu Chen2Shaochong Zhang3Shenzhen Eye Hospital, Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen, ChinaAffiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, ChinaShenzhen Eye Hospital, Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen, ChinaShenzhen Eye Hospital, Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen, ChinaPurpose: To describe the longitudinal structural changes of myopic traction maculopathy (MTM) based on optical coherence tomography (OCT) and to detect biomarkers in the evolution of MTM.Methods: A retrospective study was conducted on patients with MTM as defined by OCT. A minimum follow-up of 6 months was necessary for study inclusion. The effects of comprehensive OCT-based structure on the evolution of MTM, the progression rates, and resolution rates of MTM were evaluated.Results: A total of 120 eyes (120 patients) were included with an average follow-up of 15.4 months. During the follow-up, MTM progressed in 32 eyes (26.67%). The most common pattern of progression observed was the increased extent of retinoschisis in 12 eyes. The multivariate analysis showed that the presence of MTM progression had a significant correlation with internal limiting membrane (ILM) detachment and retinoschisis involved the entire macula at baseline. Five eyes (4.17%) experienced MTM resolution, of which 2 eyes developed disruptions of detached ILM, two eyes developed disruptions of epiretinal membrane, and one eye developed partial posterior vitreous detachment. Eyes with foveal detachment showed the highest progression rate (41.67%) and highest resolution rate (16.67%) compared to the eyes with other foveal complications.Conclusion: ILM detachment is a risk factor for MTM progression and MTM resolution can occur after ILM disruption. These suggest that ILM may play an important role as a biomarker in the evolution of MTM.https://www.frontiersin.org/articles/10.3389/fmed.2021.802626/fullinternal limiting membraneoptical coherence tomographyevolutionbiomarkermyopic traction maculopathy (MTM) |
| spellingShingle | Dong Fang Jindi Su Lu Chen Shaochong Zhang The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy Frontiers in Medicine internal limiting membrane optical coherence tomography evolution biomarker myopic traction maculopathy (MTM) |
| title | The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy |
| title_full | The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy |
| title_fullStr | The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy |
| title_full_unstemmed | The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy |
| title_short | The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy |
| title_sort | role of internal limiting membrane as a biomarker in the evolution of myopic traction maculopathy |
| topic | internal limiting membrane optical coherence tomography evolution biomarker myopic traction maculopathy (MTM) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.802626/full |
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