Diabetes mellitus exacerbates post‐myocardial infarction heart failure by reducing sarcolipin promoter methylation

Diabetes mellitus exacerbates post‐myocardial infarction heart failure by reducing sarcolipin promoter methylation

Abstract Aims Sarcolipin (SLN) is a key regulator of sarcoplasmic reticulum calcium‐ATPase (SERCA)2a, which handles intracellular calcium re‐uptake. This study was aimed to investigate the involvement of SLN in post‐myocardial infarction (MI) heart failure (HF) in diabetes. Methods and results Diabe...

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Bibliographic Details
Main Authors: Zhongwei Liu, Yong Zhang, Chuan Qiu, Haitao Zhu, Shuo Pan, Hao Jia, Hongyan Kang, Gongchang Guan, Rutai Hui, Ling Zhu, Junkui Wang
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:ESC Heart Failure
Subjects:
Diabetes mellitus
Myocardial infarction
Heart failure
Sarcolipin
Online Access:https://doi.org/10.1002/ehf2.12789

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