The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn
Background. The prevalence of vitamin D deficiency appears to be increasing worldwide. Pregnant women are at risk of developing vitamin D deficiency. Vitamin D status has a great impact on both pregnancy and the fetus. Vitamin D deficiency during pregnancy has been associated with several adverse pr...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2023-03-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
| Subjects: | |
| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1239 |
| _version_ | 1797811193080971264 |
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| author | T.O. Budnik A.V. Boychuk |
| author_facet | T.O. Budnik A.V. Boychuk |
| author_sort | T.O. Budnik |
| collection | DOAJ |
| description | Background. The prevalence of vitamin D deficiency appears to be increasing worldwide. Pregnant women are at risk of developing vitamin D deficiency. Vitamin D status has a great impact on both pregnancy and the fetus. Vitamin D deficiency during pregnancy has been associated with several adverse pregnancy outcomes. The purpose of the study was to evaluate serum vitamin D level during the first trimester of pregnancy and its effect on the neonatal anthropometric measures. Material and methods. A prospective study among 71 pregnant women aged 19 to 42 years in the first trimester was carried out between October 2018 to April 2020. A survey of pregnant women (socio-demographic characteristics, anamnestic data and diet) was conducted, and the maternal serum total vitamin D level was determined by enzyme immunoassay. Neonatal anthropometric parameters (weight, body length, weight/length ratio) were measured. Results. Vitamin D deficiency was observed in 41 (57.7 %) of pregnant women, insufficiency in 7 (9.9 %), and the optimal level in 23 (32.4 %) of examined women. Women with vitamin D deficiency were more likely to have a history of miscarriage than those with optimal D status (odds ratio 9.06, 95% confidence interval 1.11–73.86, Р = 0.0396). We have not found the influence of other factors (age, social status, body mass index, number of pregnancies) on the maternal vitamin D level. There were no significant differences between indicators of weight by age, body length of a child by age, and Apgar scores depending on the vitamin D levels of pregnant women. Conclusions. The study showed that the optimal vitamin D level is observed only in 32.4 % of cases, and its deficiency or insufficiency occurs in 67.6 % of pregnant women in the first trimester. The study did not reveal the correlation between maternal vitamin D level during the first trimester of pregnancy and neonatal anthropometric measures. Given the trend towards lower weight/length ratio to gestational age of the newborns from mothers with vitamin D deficiency, further studies are needed. |
| first_indexed | 2024-03-13T07:19:00Z |
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| id | doaj.art-4f8cb908549c44f1aa33f7d2cea7ea07 |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-03-13T07:19:00Z |
| publishDate | 2023-03-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-4f8cb908549c44f1aa33f7d2cea7ea072023-06-04T19:49:27ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272023-03-01191323810.22141/2224-0721.19.1.2023.12391237The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newbornT.O. Budnik0https://orcid.org/0000-0001-8233-6904A.V. Boychuk1https://orcid.org/0000-0002-2191-0383I. Нorbachevsky Ternopil National Medical University, Ternopil, UkraineI. Нorbachevsky Ternopil National Medical University, Ternopil, UkraineBackground. The prevalence of vitamin D deficiency appears to be increasing worldwide. Pregnant women are at risk of developing vitamin D deficiency. Vitamin D status has a great impact on both pregnancy and the fetus. Vitamin D deficiency during pregnancy has been associated with several adverse pregnancy outcomes. The purpose of the study was to evaluate serum vitamin D level during the first trimester of pregnancy and its effect on the neonatal anthropometric measures. Material and methods. A prospective study among 71 pregnant women aged 19 to 42 years in the first trimester was carried out between October 2018 to April 2020. A survey of pregnant women (socio-demographic characteristics, anamnestic data and diet) was conducted, and the maternal serum total vitamin D level was determined by enzyme immunoassay. Neonatal anthropometric parameters (weight, body length, weight/length ratio) were measured. Results. Vitamin D deficiency was observed in 41 (57.7 %) of pregnant women, insufficiency in 7 (9.9 %), and the optimal level in 23 (32.4 %) of examined women. Women with vitamin D deficiency were more likely to have a history of miscarriage than those with optimal D status (odds ratio 9.06, 95% confidence interval 1.11–73.86, Р = 0.0396). We have not found the influence of other factors (age, social status, body mass index, number of pregnancies) on the maternal vitamin D level. There were no significant differences between indicators of weight by age, body length of a child by age, and Apgar scores depending on the vitamin D levels of pregnant women. Conclusions. The study showed that the optimal vitamin D level is observed only in 32.4 % of cases, and its deficiency or insufficiency occurs in 67.6 % of pregnant women in the first trimester. The study did not reveal the correlation between maternal vitamin D level during the first trimester of pregnancy and neonatal anthropometric measures. Given the trend towards lower weight/length ratio to gestational age of the newborns from mothers with vitamin D deficiency, further studies are needed.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1239vitamin dpregnancyneonatal anthropometric measures |
| spellingShingle | T.O. Budnik A.V. Boychuk The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn Mìžnarodnij Endokrinologìčnij Žurnal vitamin d pregnancy neonatal anthropometric measures |
| title | The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn |
| title_full | The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn |
| title_fullStr | The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn |
| title_full_unstemmed | The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn |
| title_short | The level of vitamin D in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn |
| title_sort | level of vitamin d in the first trimester of pregnancy and its effect on the anthropometric parameters of а newborn |
| topic | vitamin d pregnancy neonatal anthropometric measures |
| url | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1239 |
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