Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
<p>Abstract</p> <p>Background</p> <p>Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of schizophrenic patients,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-01-01
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| Series: | BMC Psychiatry |
| Online Access: | http://www.biomedcentral.com/1471-244X/5/6 |
| _version_ | 1831614533890736128 |
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| author | Lindström Leif H Nordin Conny Shimizu Eiji Engberg Göran Hashimoto Kenji Iyo Masaomi |
| author_facet | Lindström Leif H Nordin Conny Shimizu Eiji Engberg Göran Hashimoto Kenji Iyo Masaomi |
| author_sort | Lindström Leif H |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of schizophrenic patients, and absent for glutamine. This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients.</p> <p>Method</p> <p>Levels of glutamine and glutamate in CSF of 25 first episode and drug-naive male schizophrenic patients and 17 age-matched male healthy controls were measured by a high performance liquid chromatography.</p> <p>Results</p> <p>The ratio (126.1 (median), 117.7 ± 27.4 (mean ± S.D.)) of glutamine to glutamate in the CSF of patients was significantly (z = -3.29, p = 0.001) higher than that (81.01 (median), 89.1 ± 22.5 (mean ± S.D.)) of normal controls although each level of glutamine and glutamate in patients was not different from that of normal controls.</p> <p>Conclusion</p> <p>Our data suggests that a disfunction in glutamate-glutamine cycle in the brain may play a role in the pathophysiology of schizophrenia.</p> |
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| format | Article |
| id | doaj.art-4f8ee75f87464012a4c0cd7da04ea4b4 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-18T19:31:05Z |
| publishDate | 2005-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-4f8ee75f87464012a4c0cd7da04ea4b42022-12-21T20:55:44ZengBMCBMC Psychiatry1471-244X2005-01-0151610.1186/1471-244X-5-6Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patientsLindström Leif HNordin ConnyShimizu EijiEngberg GöranHashimoto KenjiIyo Masaomi<p>Abstract</p> <p>Background</p> <p>Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of schizophrenic patients, and absent for glutamine. This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients.</p> <p>Method</p> <p>Levels of glutamine and glutamate in CSF of 25 first episode and drug-naive male schizophrenic patients and 17 age-matched male healthy controls were measured by a high performance liquid chromatography.</p> <p>Results</p> <p>The ratio (126.1 (median), 117.7 ± 27.4 (mean ± S.D.)) of glutamine to glutamate in the CSF of patients was significantly (z = -3.29, p = 0.001) higher than that (81.01 (median), 89.1 ± 22.5 (mean ± S.D.)) of normal controls although each level of glutamine and glutamate in patients was not different from that of normal controls.</p> <p>Conclusion</p> <p>Our data suggests that a disfunction in glutamate-glutamine cycle in the brain may play a role in the pathophysiology of schizophrenia.</p>http://www.biomedcentral.com/1471-244X/5/6 |
| spellingShingle | Lindström Leif H Nordin Conny Shimizu Eiji Engberg Göran Hashimoto Kenji Iyo Masaomi Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients BMC Psychiatry |
| title | Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients |
| title_full | Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients |
| title_fullStr | Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients |
| title_full_unstemmed | Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients |
| title_short | Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients |
| title_sort | elevated glutamine glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients |
| url | http://www.biomedcentral.com/1471-244X/5/6 |
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