Advancing Therapies for Cancer—From Mustard Gas to CAR T
The development of targeted therapeutics for cancer continues to receive intense research attention as laboratories and pharmaceutical companies seek to develop drugs and technologies that improve treatment efficacy and mitigate harmful side effects. In the aftermath of World War I, it was discovere...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Sci |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2413-4155/2/4/90 |
| _version_ | 1797545508698324992 |
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| author | Dillon K. Jarrell Seth Drake Mark A. Brown |
| author_facet | Dillon K. Jarrell Seth Drake Mark A. Brown |
| author_sort | Dillon K. Jarrell |
| collection | DOAJ |
| description | The development of targeted therapeutics for cancer continues to receive intense research attention as laboratories and pharmaceutical companies seek to develop drugs and technologies that improve treatment efficacy and mitigate harmful side effects. In the aftermath of World War I, it was discovered that mustard gas destroys rapidly dividing cells and could be used to treat cancer. Since then, chemotherapy has remained a predominant treatment for cancer; however, the destruction of dividing cells throughout the body yields devastating side effects including off-target damage of the digestive tract, bone marrow, skin, and reproductive tract. Furthermore, the high mutation rate of cancerous cells often renders chemotherapy ineffective long-term. Therapies with improved specificity, localization, and efficacy are redefining cancer treatment. Herein, we define and summarize the principal advancements in targeted cancer treatment and briefly comment on the march towards personalized medicine in the treatment of human cancer. |
| first_indexed | 2024-03-10T14:17:23Z |
| format | Article |
| id | doaj.art-4f92527428984e978886127f304ba8f5 |
| institution | Directory Open Access Journal |
| issn | 2413-4155 |
| language | English |
| last_indexed | 2024-03-10T14:17:23Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sci |
| spelling | doaj.art-4f92527428984e978886127f304ba8f52023-11-20T23:42:10ZengMDPI AGSci2413-41552020-12-01249010.3390/sci2040090Advancing Therapies for Cancer—From Mustard Gas to CAR TDillon K. Jarrell0Seth Drake1Mark A. Brown2Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USACell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USAThe development of targeted therapeutics for cancer continues to receive intense research attention as laboratories and pharmaceutical companies seek to develop drugs and technologies that improve treatment efficacy and mitigate harmful side effects. In the aftermath of World War I, it was discovered that mustard gas destroys rapidly dividing cells and could be used to treat cancer. Since then, chemotherapy has remained a predominant treatment for cancer; however, the destruction of dividing cells throughout the body yields devastating side effects including off-target damage of the digestive tract, bone marrow, skin, and reproductive tract. Furthermore, the high mutation rate of cancerous cells often renders chemotherapy ineffective long-term. Therapies with improved specificity, localization, and efficacy are redefining cancer treatment. Herein, we define and summarize the principal advancements in targeted cancer treatment and briefly comment on the march towards personalized medicine in the treatment of human cancer.https://www.mdpi.com/2413-4155/2/4/90small molecule inhibitorpersonalized medicineprecision medicineoncologytargeted therapydrug delivery |
| spellingShingle | Dillon K. Jarrell Seth Drake Mark A. Brown Advancing Therapies for Cancer—From Mustard Gas to CAR T Sci small molecule inhibitor personalized medicine precision medicine oncology targeted therapy drug delivery |
| title | Advancing Therapies for Cancer—From Mustard Gas to CAR T |
| title_full | Advancing Therapies for Cancer—From Mustard Gas to CAR T |
| title_fullStr | Advancing Therapies for Cancer—From Mustard Gas to CAR T |
| title_full_unstemmed | Advancing Therapies for Cancer—From Mustard Gas to CAR T |
| title_short | Advancing Therapies for Cancer—From Mustard Gas to CAR T |
| title_sort | advancing therapies for cancer from mustard gas to car t |
| topic | small molecule inhibitor personalized medicine precision medicine oncology targeted therapy drug delivery |
| url | https://www.mdpi.com/2413-4155/2/4/90 |
| work_keys_str_mv | AT dillonkjarrell advancingtherapiesforcancerfrommustardgastocart AT sethdrake advancingtherapiesforcancerfrommustardgastocart AT markabrown advancingtherapiesforcancerfrommustardgastocart |