Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System
Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2020.600758/full |
| _version_ | 1831806279229636608 |
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| author | Isis Zhang Huijuan Hu |
| author_facet | Isis Zhang Huijuan Hu |
| author_sort | Isis Zhang |
| collection | DOAJ |
| description | Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cells, attention has turned to their role in neurons and glia in recent years. In particular, the role of SOCs in the nervous system has been extensively investigated, with links to their dysregulation found in a wide variety of neurological diseases from Alzheimer’s disease (AD) to pain. In this review, we provide an overview of their molecular components, expression, and physiological role in the nervous system and describe how the dysregulation of those roles could potentially lead to various neurological disorders. Although further studies are still needed to understand how SOCs are activated under physiological conditions and how they are linked to pathological states, growing evidence indicates that SOCs are important players in neurological disorders and could be potential new targets for therapies. While the role of SOCE in the nervous system continues to be multifaceted and controversial, the study of SOCs provides a potentially fruitful avenue into better understanding the nervous system and its pathologies. |
| first_indexed | 2024-12-22T19:39:52Z |
| format | Article |
| id | doaj.art-4f93c05e1bf74b20987dff7e9742a13b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T19:39:52Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-4f93c05e1bf74b20987dff7e9742a13b2022-12-21T18:14:53ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-11-011410.3389/fncel.2020.600758600758Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous SystemIsis ZhangHuijuan HuStore-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cells, attention has turned to their role in neurons and glia in recent years. In particular, the role of SOCs in the nervous system has been extensively investigated, with links to their dysregulation found in a wide variety of neurological diseases from Alzheimer’s disease (AD) to pain. In this review, we provide an overview of their molecular components, expression, and physiological role in the nervous system and describe how the dysregulation of those roles could potentially lead to various neurological disorders. Although further studies are still needed to understand how SOCs are activated under physiological conditions and how they are linked to pathological states, growing evidence indicates that SOCs are important players in neurological disorders and could be potential new targets for therapies. While the role of SOCE in the nervous system continues to be multifaceted and controversial, the study of SOCs provides a potentially fruitful avenue into better understanding the nervous system and its pathologies.https://www.frontiersin.org/articles/10.3389/fncel.2020.600758/fullstore-operated calcium channelsSTIMOrai1nervous systemneuronglia |
| spellingShingle | Isis Zhang Huijuan Hu Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System Frontiers in Cellular Neuroscience store-operated calcium channels STIM Orai1 nervous system neuron glia |
| title | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
| title_full | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
| title_fullStr | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
| title_full_unstemmed | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
| title_short | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
| title_sort | store operated calcium channels in physiological and pathological states of the nervous system |
| topic | store-operated calcium channels STIM Orai1 nervous system neuron glia |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2020.600758/full |
| work_keys_str_mv | AT isiszhang storeoperatedcalciumchannelsinphysiologicalandpathologicalstatesofthenervoussystem AT huijuanhu storeoperatedcalciumchannelsinphysiologicalandpathologicalstatesofthenervoussystem |