In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases
In this paper, we report two cases of a 62-year-old patient presented with blurred vision and a 45-year-old male diagnosed with multiple myeloma who was referred from the Department of Oncology. Slit-lamp examination, in vivo confocal microscopy (IVCM), systemic work-up and serum protein electrophor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=9;spage=938;epage=940;aulast=Kocabeyoglu |
| _version_ | 1819127245588922368 |
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| author | Sibel Kocabeyoglu Mehmet C Mocan Ibrahim C Haznedaroglu Aysegul Uner Enes Uzunosmanoglu Murat Irkec |
| author_facet | Sibel Kocabeyoglu Mehmet C Mocan Ibrahim C Haznedaroglu Aysegul Uner Enes Uzunosmanoglu Murat Irkec |
| author_sort | Sibel Kocabeyoglu |
| collection | DOAJ |
| description | In this paper, we report two cases of a 62-year-old patient presented with blurred vision and a 45-year-old male diagnosed with multiple myeloma who was referred from the Department of Oncology. Slit-lamp examination, in vivo confocal microscopy (IVCM), systemic work-up and serum protein electrophoresis were obtained. In both patients, slit-lamp findings revealed bilateral diffuse subepithelial and anterior stromal crystals and IVCM showed highly reflective deposits in the corneal epithelium and stroma. The first patient was eventually diagnosed with monoclonal gammopathy of undetermined significance following bone marrow biopsy and systemic evaluation. Unusual corneal deposits may constitute the first sign of monoclonal gammopathies. IVCM may be helpful in showing the crystalline nature of the corneal deposits and guiding the clinician to the diagnosis of gammopathies. Both ophthalmologists and oncologists should be aware that corneal deposits may herald a life-threatening hematologic disease. |
| first_indexed | 2024-12-22T08:08:52Z |
| format | Article |
| id | doaj.art-4f99b8c14ace4728b5e87f97989ba2c1 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-22T08:08:52Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-4f99b8c14ace4728b5e87f97989ba2c12022-12-21T18:33:04ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892014-01-0162993894010.4103/0301-4738.143933In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two casesSibel KocabeyogluMehmet C MocanIbrahim C HaznedarogluAysegul UnerEnes UzunosmanogluMurat IrkecIn this paper, we report two cases of a 62-year-old patient presented with blurred vision and a 45-year-old male diagnosed with multiple myeloma who was referred from the Department of Oncology. Slit-lamp examination, in vivo confocal microscopy (IVCM), systemic work-up and serum protein electrophoresis were obtained. In both patients, slit-lamp findings revealed bilateral diffuse subepithelial and anterior stromal crystals and IVCM showed highly reflective deposits in the corneal epithelium and stroma. The first patient was eventually diagnosed with monoclonal gammopathy of undetermined significance following bone marrow biopsy and systemic evaluation. Unusual corneal deposits may constitute the first sign of monoclonal gammopathies. IVCM may be helpful in showing the crystalline nature of the corneal deposits and guiding the clinician to the diagnosis of gammopathies. Both ophthalmologists and oncologists should be aware that corneal deposits may herald a life-threatening hematologic disease.http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=9;spage=938;epage=940;aulast=KocabeyogluGlaucomapressure-to-cornea indexvisual field Combined trabeculectomyglaucoma tube shunt surgerylong-term results ocular perfusion pressureopen-angle glaucomasystemic hypertension Anterior stromal opacitiesfemtosecond anterior lamellar keratoplastyspectral domain optical coherence tomography Anesthesiacataractphacoemulsificationrandomized control trail Cataractintraocular lensoptical low-coherence reflectometrypartial coherence interferometry Corneal blindnesscommunity eye bankingkeratoplastyCorneal depositsin vivo confocal microscopymonoclonal gammopathy of undetermined significancemultiple myeloma |
| spellingShingle | Sibel Kocabeyoglu Mehmet C Mocan Ibrahim C Haznedaroglu Aysegul Uner Enes Uzunosmanoglu Murat Irkec In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases Indian Journal of Ophthalmology Glaucoma pressure-to-cornea index visual field Combined trabeculectomy glaucoma tube shunt surgery long-term results ocular perfusion pressure open-angle glaucoma systemic hypertension Anterior stromal opacities femtosecond anterior lamellar keratoplasty spectral domain optical coherence tomography Anesthesia cataract phacoemulsification randomized control trail Cataract intraocular lens optical low-coherence reflectometry partial coherence interferometry Corneal blindness community eye banking keratoplasty Corneal deposits in vivo confocal microscopy monoclonal gammopathy of undetermined significance multiple myeloma |
| title | In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases |
| title_full | In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases |
| title_fullStr | In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases |
| title_full_unstemmed | In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases |
| title_short | In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases |
| title_sort | in vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy report of two cases |
| topic | Glaucoma pressure-to-cornea index visual field Combined trabeculectomy glaucoma tube shunt surgery long-term results ocular perfusion pressure open-angle glaucoma systemic hypertension Anterior stromal opacities femtosecond anterior lamellar keratoplasty spectral domain optical coherence tomography Anesthesia cataract phacoemulsification randomized control trail Cataract intraocular lens optical low-coherence reflectometry partial coherence interferometry Corneal blindness community eye banking keratoplasty Corneal deposits in vivo confocal microscopy monoclonal gammopathy of undetermined significance multiple myeloma |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=9;spage=938;epage=940;aulast=Kocabeyoglu |
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