Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms
EBV is a lymphotropic virus, member of the Herpesviridae family that asymptomatically infects more than 90% of the human population, establishing a latent infection in memory B cells. EBV exhibits complex survival and persistence dynamics, replicating its genome through the proliferation of infected...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1240359/full |
| _version_ | 1827818308433346560 |
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| author | Mario Henrique M. Barros Paula Daniela S. Alves |
| author_facet | Mario Henrique M. Barros Paula Daniela S. Alves |
| author_sort | Mario Henrique M. Barros |
| collection | DOAJ |
| description | EBV is a lymphotropic virus, member of the Herpesviridae family that asymptomatically infects more than 90% of the human population, establishing a latent infection in memory B cells. EBV exhibits complex survival and persistence dynamics, replicating its genome through the proliferation of infected B cells or production of the lytic virions. Many studies have documented the infection of T/NK cells by EBV in healthy individuals during and after primary infection. This feature has been confirmed in humanized mouse models. Together these results have challenged the hypothesis that the infection of T/NK cells per se by EBV could be a triggering event for lymphomagenesis. Extranodal NK/T-cell lymphoma (ENKTCL) and Epstein-Barr virus (EBV)-positive nodal T- and NK-cell lymphoma (NKTCL) are two EBV-associated lymphomas of T/NK cells. These two lymphomas display different clinical, histological and molecular features. However, they share two intriguing characteristics: the association with EBV and a geographical prevalence in East Asia and Latin America. In this review we will discuss the genetic characteristics of EBV in order to understand the possible role of this virus in the oncogenesis of ENKTCL and NKTCL. In addition, the main immunohistological, molecular, cytogenetic and epigenetic differences between ENKTCL and NKTCL will be discussed, as well as EBV differences in latency patterns and other viral molecular characteristics. |
| first_indexed | 2024-03-12T00:45:58Z |
| format | Article |
| id | doaj.art-4f9a7c5f74ef4f80b31e6a2887f3e98b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T00:45:58Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4f9a7c5f74ef4f80b31e6a2887f3e98b2023-09-14T17:19:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.12403591240359Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasmsMario Henrique M. Barros0Paula Daniela S. Alves1Institute of Pathology, Klinikum Chemnitz, Chemnitz, GermanyOncovirology Laboratory, Bone Marrow Transplantation Center, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, BrazilEBV is a lymphotropic virus, member of the Herpesviridae family that asymptomatically infects more than 90% of the human population, establishing a latent infection in memory B cells. EBV exhibits complex survival and persistence dynamics, replicating its genome through the proliferation of infected B cells or production of the lytic virions. Many studies have documented the infection of T/NK cells by EBV in healthy individuals during and after primary infection. This feature has been confirmed in humanized mouse models. Together these results have challenged the hypothesis that the infection of T/NK cells per se by EBV could be a triggering event for lymphomagenesis. Extranodal NK/T-cell lymphoma (ENKTCL) and Epstein-Barr virus (EBV)-positive nodal T- and NK-cell lymphoma (NKTCL) are two EBV-associated lymphomas of T/NK cells. These two lymphomas display different clinical, histological and molecular features. However, they share two intriguing characteristics: the association with EBV and a geographical prevalence in East Asia and Latin America. In this review we will discuss the genetic characteristics of EBV in order to understand the possible role of this virus in the oncogenesis of ENKTCL and NKTCL. In addition, the main immunohistological, molecular, cytogenetic and epigenetic differences between ENKTCL and NKTCL will be discussed, as well as EBV differences in latency patterns and other viral molecular characteristics.https://www.frontiersin.org/articles/10.3389/fonc.2023.1240359/fullEpstein-Barr virusT-cell lymphomaEBV-positive nodal T-and NK-cell lymphomaextranodal NK/T-cell lymphomainfectious mononucleosisLMP1 |
| spellingShingle | Mario Henrique M. Barros Paula Daniela S. Alves Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms Frontiers in Oncology Epstein-Barr virus T-cell lymphoma EBV-positive nodal T-and NK-cell lymphoma extranodal NK/T-cell lymphoma infectious mononucleosis LMP1 |
| title | Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms |
| title_full | Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms |
| title_fullStr | Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms |
| title_full_unstemmed | Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms |
| title_short | Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms |
| title_sort | contribution of the epstein barr virus to the oncogenesis of mature t cell lymphoproliferative neoplasms |
| topic | Epstein-Barr virus T-cell lymphoma EBV-positive nodal T-and NK-cell lymphoma extranodal NK/T-cell lymphoma infectious mononucleosis LMP1 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1240359/full |
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