Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America
<i>Introduction</i>: The effect of the lipidosterolic extract derived from <i>Serenoa repens</i> (commonly known as “saw palmetto extract” or LSESr) berries on benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS) has been extensively studied in the...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2673-4397/2/3/17 |
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| author | J. Curtis Nickel Bilal Chughtai Cosimo De Nunzio Jamin Brahmbhatt Neal Shore Alexis E. Te Bob Djavan |
| author_facet | J. Curtis Nickel Bilal Chughtai Cosimo De Nunzio Jamin Brahmbhatt Neal Shore Alexis E. Te Bob Djavan |
| author_sort | J. Curtis Nickel |
| collection | DOAJ |
| description | <i>Introduction</i>: The effect of the lipidosterolic extract derived from <i>Serenoa repens</i> (commonly known as “saw palmetto extract” or LSESr) berries on benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS) has been extensively studied in the global literature. However, a lack of global consensus with regard to its effectiveness remains, resulting in differing recommendations on the role of LSESr in the BPH/LUTS treatment paradigm. Here, we describe the consensus reached by an international panel of urology experts. <i>Methods</i>: In an independent meeting on 24 April 2021, an international panel of urology experts convened with the goal of developing consensus statements to address the following: the differences between the AUA and EAU guidance regarding the use of LSESr for the treatment of BPH/LUTS, the proposed mechanism of action of LSESr, and data examining the efficacy and safety of LSESr. These consensus statements were developed over the course of several months after an extensive review of the global literature and a discussion thereof. <i>Results</i>: A total of seven consensus statements were agreed upon by the panel. These statements addressed the proposed mechanism of action of LSESr, LSESr quality, and the results from clinical trials examining the efficacy and safety of various LSESrs. <i>Conclusion</i>: Based on the reviewed evidence, the panel recommends that LSESr should be considered as a treatment option for men with mild-to-moderate BPH/LUTS as an alternative to watchful waiting. |
| first_indexed | 2024-03-09T22:18:08Z |
| format | Article |
| id | doaj.art-4f9d9dbb56904688846e8b9b96d26a31 |
| institution | Directory Open Access Journal |
| issn | 2673-4397 |
| language | English |
| last_indexed | 2024-03-09T22:18:08Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Uro |
| spelling | doaj.art-4f9d9dbb56904688846e8b9b96d26a312023-11-23T19:19:48ZengMDPI AGUro2673-43972022-06-012313715010.3390/uro2030017Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North AmericaJ. Curtis Nickel0Bilal Chughtai1Cosimo De Nunzio2Jamin Brahmbhatt3Neal Shore4Alexis E. Te5Bob Djavan6Department of Urology, Queens University, Kingston, ON K7L 3N6, CanadaDepartment of Urology, Weill Cornell Medical College, New York, NY 10021, USADivision of Urology, Sapienza University of Rome, Ospedale Sant’Andrea, 00189 Rome, ItalyDepartment of Urology, Orlando Health, UCF College of Medicine, Orlando, FL 32827, USACarolina Urologic Research Center/GenesisCare, Myrtle Beach, SC 29572, USADepartment of Urology, Weill Cornell Medical College, New York, NY 10021, USADepartment of Urology, Rudolfinerhaus Foundation Hospital, A-1190 Vienna, Austria<i>Introduction</i>: The effect of the lipidosterolic extract derived from <i>Serenoa repens</i> (commonly known as “saw palmetto extract” or LSESr) berries on benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS) has been extensively studied in the global literature. However, a lack of global consensus with regard to its effectiveness remains, resulting in differing recommendations on the role of LSESr in the BPH/LUTS treatment paradigm. Here, we describe the consensus reached by an international panel of urology experts. <i>Methods</i>: In an independent meeting on 24 April 2021, an international panel of urology experts convened with the goal of developing consensus statements to address the following: the differences between the AUA and EAU guidance regarding the use of LSESr for the treatment of BPH/LUTS, the proposed mechanism of action of LSESr, and data examining the efficacy and safety of LSESr. These consensus statements were developed over the course of several months after an extensive review of the global literature and a discussion thereof. <i>Results</i>: A total of seven consensus statements were agreed upon by the panel. These statements addressed the proposed mechanism of action of LSESr, LSESr quality, and the results from clinical trials examining the efficacy and safety of various LSESrs. <i>Conclusion</i>: Based on the reviewed evidence, the panel recommends that LSESr should be considered as a treatment option for men with mild-to-moderate BPH/LUTS as an alternative to watchful waiting.https://www.mdpi.com/2673-4397/2/3/17lower urinary tract symptomsbenign prostate hyperplasiaNorth Americasaw palmetto |
| spellingShingle | J. Curtis Nickel Bilal Chughtai Cosimo De Nunzio Jamin Brahmbhatt Neal Shore Alexis E. Te Bob Djavan Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America Uro lower urinary tract symptoms benign prostate hyperplasia North America saw palmetto |
| title | Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America |
| title_full | Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America |
| title_fullStr | Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America |
| title_full_unstemmed | Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America |
| title_short | Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America |
| title_sort | rethinking the role of saw palmetto extract for men with lower urinary tract symptoms in north america |
| topic | lower urinary tract symptoms benign prostate hyperplasia North America saw palmetto |
| url | https://www.mdpi.com/2673-4397/2/3/17 |
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