Deficits in neural encoding of speech in preterm infants
Preterm children show developmental cognitive and language deficits that can be subtle and sometimes undetectable until later in life. Studies of brain development in children who are born preterm have largely focused on vascular and gross anatomical characteristics rather than pathophysiological pr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000646 |
| _version_ | 1827923893475606528 |
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| author | Nikolay Novitskiy Peggy H.Y. Chan Mavis Chan Chin Man Lai Tak Yeung Leung Ting Fan Leung Marc H. Bornstein Hugh S. Lam Patrick C.M. Wong |
| author_facet | Nikolay Novitskiy Peggy H.Y. Chan Mavis Chan Chin Man Lai Tak Yeung Leung Ting Fan Leung Marc H. Bornstein Hugh S. Lam Patrick C.M. Wong |
| author_sort | Nikolay Novitskiy |
| collection | DOAJ |
| description | Preterm children show developmental cognitive and language deficits that can be subtle and sometimes undetectable until later in life. Studies of brain development in children who are born preterm have largely focused on vascular and gross anatomical characteristics rather than pathophysiological processes that may contribute to these developmental deficits. Neural encoding of speech as reflected in EEG recordings is predictive of future language development and could provide insights into those pathophysiological processes. We recorded EEG from 45 preterm (≤ 34 weeks of gestation) and 45 term (≥ 38 weeks) Chinese-learning infants 0–12 months of (corrected) age during natural sleep. Each child listened to three speech stimuli that differed in lexically meaningful pitch (2 native and 1 non-native speech categories). EEG measures associated with synchronization and gross power of the frequency following response (FFR) were examined. ANCOVAs revealed no main effect of stimulus nativeness but main effects of age, consistent with earlier studies. A main effect of prematurity also emerged, with synchronization measures showing stronger group differences than power. By detailing differences in FFR measures related to synchronization and power, this study brings us closer to identifying the pathophysiological pathway to often subtle language problems experienced by preterm children. |
| first_indexed | 2024-03-13T05:02:59Z |
| format | Article |
| id | doaj.art-4f9ee8cfc62c46488a5d69e8c34584c8 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-13T05:02:59Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-4f9ee8cfc62c46488a5d69e8c34584c82023-06-17T05:18:00ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-06-0161101259Deficits in neural encoding of speech in preterm infantsNikolay Novitskiy0Peggy H.Y. Chan1Mavis Chan2Chin Man Lai3Tak Yeung Leung4Ting Fan Leung5Marc H. Bornstein6Hugh S. Lam7Patrick C.M. Wong8Brain and Mind Institute, The Chinese University of Hong Kong, Hong Kong, ChinaBrain and Mind Institute, The Chinese University of Hong Kong, Hong Kong, China; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, ChinaBrain and Mind Institute, The Chinese University of Hong Kong, Hong Kong, ChinaBrain and Mind Institute, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Obsterics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics, The Chinese University of Hong Kong, Hong Kong, ChinaEunice Kennedy Shriver National Institute of Child Health and Human Development, USA; UNICEF, USA; Institute for Fiscal Studies, UKDepartment of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China; Corresponding author.Brain and Mind Institute, The Chinese University of Hong Kong, Hong Kong, China; Correspondence to: Dept. of Linguistics & Modern Languages, The Chinese University of Hong Kong, Hong Kong, China.Preterm children show developmental cognitive and language deficits that can be subtle and sometimes undetectable until later in life. Studies of brain development in children who are born preterm have largely focused on vascular and gross anatomical characteristics rather than pathophysiological processes that may contribute to these developmental deficits. Neural encoding of speech as reflected in EEG recordings is predictive of future language development and could provide insights into those pathophysiological processes. We recorded EEG from 45 preterm (≤ 34 weeks of gestation) and 45 term (≥ 38 weeks) Chinese-learning infants 0–12 months of (corrected) age during natural sleep. Each child listened to three speech stimuli that differed in lexically meaningful pitch (2 native and 1 non-native speech categories). EEG measures associated with synchronization and gross power of the frequency following response (FFR) were examined. ANCOVAs revealed no main effect of stimulus nativeness but main effects of age, consistent with earlier studies. A main effect of prematurity also emerged, with synchronization measures showing stronger group differences than power. By detailing differences in FFR measures related to synchronization and power, this study brings us closer to identifying the pathophysiological pathway to often subtle language problems experienced by preterm children.http://www.sciencedirect.com/science/article/pii/S1878929323000646Preterm infantsFFRMyelinationSpeechSynaptogenesis |
| spellingShingle | Nikolay Novitskiy Peggy H.Y. Chan Mavis Chan Chin Man Lai Tak Yeung Leung Ting Fan Leung Marc H. Bornstein Hugh S. Lam Patrick C.M. Wong Deficits in neural encoding of speech in preterm infants Developmental Cognitive Neuroscience Preterm infants FFR Myelination Speech Synaptogenesis |
| title | Deficits in neural encoding of speech in preterm infants |
| title_full | Deficits in neural encoding of speech in preterm infants |
| title_fullStr | Deficits in neural encoding of speech in preterm infants |
| title_full_unstemmed | Deficits in neural encoding of speech in preterm infants |
| title_short | Deficits in neural encoding of speech in preterm infants |
| title_sort | deficits in neural encoding of speech in preterm infants |
| topic | Preterm infants FFR Myelination Speech Synaptogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000646 |
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