<i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond
Over the last decades, fungal infections have emerged as a growing threat to human health. Although the human body is at potential risk, various body sites host several commensal fungal species, including <i>Candida albicans</i>. In healthy individuals, <i>C. albicans</i> col...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/8/1/40 |
| _version_ | 1798006306001387520 |
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| author | Marc Swidergall |
| author_facet | Marc Swidergall |
| author_sort | Marc Swidergall |
| collection | DOAJ |
| description | Over the last decades, fungal infections have emerged as a growing threat to human health. Although the human body is at potential risk, various body sites host several commensal fungal species, including <i>Candida albicans</i>. In healthy individuals, <i>C. albicans</i> colonizes different mucosal surfaces without causing harm, while under diverse circumstances the fungus can proliferate and cause disease. In this context, the understanding of host–<i>C. albicans</i> interactions in health and during infection may lead to novel therapeutic approaches. Importantly, host cells express pattern recognition receptors (PRRs), which sense conserved fungal structures and orchestrate innate immune responses. Herein, important findings on the topic of the recognition of <i>C. albicans</i> at host barrier sites are discussed. This review briefly summarizes the importance and functions of myeloid PRRs, reviews the fungal recognition and biology of stromal cells, and highlights important <i>C. albicans</i> virulence attributes during site-specific proliferation and invasion. |
| first_indexed | 2024-04-11T12:53:51Z |
| format | Article |
| id | doaj.art-4fa08f960c4640ff851198808b37eb73 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T12:53:51Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-4fa08f960c4640ff851198808b37eb732022-12-22T04:23:08ZengMDPI AGPathogens2076-08172019-03-01814010.3390/pathogens8010040pathogens8010040<i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and BeyondMarc Swidergall0Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA 90502, USAOver the last decades, fungal infections have emerged as a growing threat to human health. Although the human body is at potential risk, various body sites host several commensal fungal species, including <i>Candida albicans</i>. In healthy individuals, <i>C. albicans</i> colonizes different mucosal surfaces without causing harm, while under diverse circumstances the fungus can proliferate and cause disease. In this context, the understanding of host–<i>C. albicans</i> interactions in health and during infection may lead to novel therapeutic approaches. Importantly, host cells express pattern recognition receptors (PRRs), which sense conserved fungal structures and orchestrate innate immune responses. Herein, important findings on the topic of the recognition of <i>C. albicans</i> at host barrier sites are discussed. This review briefly summarizes the importance and functions of myeloid PRRs, reviews the fungal recognition and biology of stromal cells, and highlights important <i>C. albicans</i> virulence attributes during site-specific proliferation and invasion.https://www.mdpi.com/2076-0817/8/1/40antifungal immunityhost–fungus interactionmucosal tissue |
| spellingShingle | Marc Swidergall <i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond Pathogens antifungal immunity host–fungus interaction mucosal tissue |
| title | <i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond |
| title_full | <i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond |
| title_fullStr | <i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond |
| title_full_unstemmed | <i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond |
| title_short | <i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond |
| title_sort | i candida albicans i at host barrier sites pattern recognition receptors and beyond |
| topic | antifungal immunity host–fungus interaction mucosal tissue |
| url | https://www.mdpi.com/2076-0817/8/1/40 |
| work_keys_str_mv | AT marcswidergall icandidaalbicansiathostbarriersitespatternrecognitionreceptorsandbeyond |