RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER
To date, there is growing number of well-known predictors of malignancy of the thyroid nodules including a solid fixed formation that is detected by physiological examination, rapid growth and large size of the site, tracheostomy, dysphagia or lymphadenopathy, irradiation in the history of low doses...
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| Format: | Article |
| Language: | English |
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Ukrainian Medical Stomatological Academy
2018-12-01
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| Series: | Вісник проблем біології і медицини |
| Subjects: | |
| Online Access: | https://vpbm.com.ua/upload/2018-4-2/18-min.pdf |
| _version_ | 1811257800544747520 |
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| author | Chernenko O. V. |
| author_facet | Chernenko O. V. |
| author_sort | Chernenko O. V. |
| collection | DOAJ |
| description | To date, there is growing number of well-known predictors of malignancy of the thyroid nodules including a solid fixed formation that is detected by physiological examination, rapid growth and large size of the site, tracheostomy, dysphagia or lymphadenopathy, irradiation in the history of low doses of radiation of the head and neck in infancy, age less for 20 years and more than 70 years and male gender. Detection of thyroid tumors, characterized by benign course and favorable prognosis, can significantly reduce the number of surgical interventions. However, there are cases where the potential of malignancy of the tumor can not be determined. In this case, alternative diagnostic methods are required. These may include the detection of BRAF and RAS spot mutations, PAX8 / PPAR? and RET / PTC translocation, but given the high cost of research data and relatively low sensitivity, these methods are not always suitable for routine diagnostics. The determination of the level of serum hormones may be cheaper and faster. This review is devoted to the assessment of the current concept on thyroid stimulating hormone role in development and progression differentiated thyroid cancer, namely papillary thyroid carcinoma. Numerous studies demonstrated the significance of high (TSH) in thyroid nodes malignisation and progression associated with rapid growth, aggressiveness and metastasis development. Many authors find this test useful for distinguishing benign and malignant thyroid tumors and suggest that it may be used as an auxiliary in the diagnostics. However there some authors who did not find any relationship between TSH and thyroid cancer. Finally, there is a growing body of investigations demonstrating the opposite relations between TSH levels and thyroid malignancies. Genetic studies also are in favor of the reciprocal association between the level of TSH and the development of thyroid cancer. Such controversy could be related with different sampling and design of study as well as with confounding factors including patients age, benign thyroid nodules with autonomy and autoimmune thyroiditis. |
| first_indexed | 2024-04-12T18:03:15Z |
| format | Article |
| id | doaj.art-4fa1024927ed4c18962c3650abf5864c |
| institution | Directory Open Access Journal |
| issn | 2077-4214 2523-4110 |
| language | English |
| last_indexed | 2024-04-12T18:03:15Z |
| publishDate | 2018-12-01 |
| publisher | Ukrainian Medical Stomatological Academy |
| record_format | Article |
| series | Вісник проблем біології і медицини |
| spelling | doaj.art-4fa1024927ed4c18962c3650abf5864c2022-12-22T03:22:04ZengUkrainian Medical Stomatological AcademyВісник проблем біології і медицини2077-42142523-41102018-12-012484-810.29254/2077-4214-2018-4-2-147-84-882077-4214-2018-4-2-147-84-88RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCERChernenko O. V.0 Ukrainian sciences-practical center of endocrine surgery,transplantation of endocrine organs and tissues MOH of UkraineTo date, there is growing number of well-known predictors of malignancy of the thyroid nodules including a solid fixed formation that is detected by physiological examination, rapid growth and large size of the site, tracheostomy, dysphagia or lymphadenopathy, irradiation in the history of low doses of radiation of the head and neck in infancy, age less for 20 years and more than 70 years and male gender. Detection of thyroid tumors, characterized by benign course and favorable prognosis, can significantly reduce the number of surgical interventions. However, there are cases where the potential of malignancy of the tumor can not be determined. In this case, alternative diagnostic methods are required. These may include the detection of BRAF and RAS spot mutations, PAX8 / PPAR? and RET / PTC translocation, but given the high cost of research data and relatively low sensitivity, these methods are not always suitable for routine diagnostics. The determination of the level of serum hormones may be cheaper and faster. This review is devoted to the assessment of the current concept on thyroid stimulating hormone role in development and progression differentiated thyroid cancer, namely papillary thyroid carcinoma. Numerous studies demonstrated the significance of high (TSH) in thyroid nodes malignisation and progression associated with rapid growth, aggressiveness and metastasis development. Many authors find this test useful for distinguishing benign and malignant thyroid tumors and suggest that it may be used as an auxiliary in the diagnostics. However there some authors who did not find any relationship between TSH and thyroid cancer. Finally, there is a growing body of investigations demonstrating the opposite relations between TSH levels and thyroid malignancies. Genetic studies also are in favor of the reciprocal association between the level of TSH and the development of thyroid cancer. Such controversy could be related with different sampling and design of study as well as with confounding factors including patients age, benign thyroid nodules with autonomy and autoimmune thyroiditis. https://vpbm.com.ua/upload/2018-4-2/18-min.pdf thyroid cancerthyroid stimulating hormone |
| spellingShingle | Chernenko O. V. RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER Вісник проблем біології і медицини thyroid cancer thyroid stimulating hormone |
| title | RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER |
| title_full | RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER |
| title_fullStr | RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER |
| title_full_unstemmed | RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER |
| title_short | RELATIONSHIP BETWEEN THYROID STIMULATING HORMONE AND THYROID CANCER |
| title_sort | relationship between thyroid stimulating hormone and thyroid cancer |
| topic | thyroid cancer thyroid stimulating hormone |
| url | https://vpbm.com.ua/upload/2018-4-2/18-min.pdf |
| work_keys_str_mv | AT chernenkoov relationshipbetweenthyroidstimulatinghormoneandthyroidcancer |