Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailabil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/9/1976 |
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| author | Tais de Cassia Ribeiro Rafael Miguel Sábio Marcela Tavares Luiz Lucas Canto de Souza Bruno Fonseca-Santos Luis Carlos Cides da Silva Márcia Carvalho de Abreu Fantini Cleopatra da Silva Planeta Marlus Chorilli |
| author_facet | Tais de Cassia Ribeiro Rafael Miguel Sábio Marcela Tavares Luiz Lucas Canto de Souza Bruno Fonseca-Santos Luis Carlos Cides da Silva Márcia Carvalho de Abreu Fantini Cleopatra da Silva Planeta Marlus Chorilli |
| author_sort | Tais de Cassia Ribeiro |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailability, besides acting over the main causes associated to AD. A thermo-responsive hydrogel is an interesting approach for facilitating the administration of the nanosystem via a nasal route, as well as for overcoming mucociliary clearance mechanisms. In light of this, MSN-CCM were dispersed in the hydrogel and evaluated through in vitro and in vivo assays. The MSNs and MSN-CCM were successfully characterized by physicochemical analysis and a high value of the CCM encapsulation efficiency (EE%, 87.70 ± 0.05) was achieved. The designed thermo-responsive hydrogel (HG) was characterized by rheology, texture profile analysis, and ex vivo mucoadhesion, showing excellent mechanical and mucoadhesive properties. Ex vivo permeation studies of MSN-CCM and HG@MSN-CCM showed high permeation values (12.46 ± 1.08 and 28.40 ± 1.88 μg cm<sup>−2</sup> of CCM, respectively) in porcine nasal mucosa. In vivo studies performed in a streptozotocin-induced AD model confirmed that HG@MSN-CCM reverted the cognitive deficit in mice, acting as a potential formulation in the treatment of AD. |
| first_indexed | 2024-03-09T22:49:19Z |
| format | Article |
| id | doaj.art-4fa18e8688c14eee837efa20b3a011fa |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:49:19Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4fa18e8688c14eee837efa20b3a011fa2023-11-23T18:23:57ZengMDPI AGPharmaceutics1999-49232022-09-01149197610.3390/pharmaceutics14091976Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease TherapyTais de Cassia Ribeiro0Rafael Miguel Sábio1Marcela Tavares Luiz2Lucas Canto de Souza3Bruno Fonseca-Santos4Luis Carlos Cides da Silva5Márcia Carvalho de Abreu Fantini6Cleopatra da Silva Planeta7Marlus Chorilli8Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilDepartment of Biotechnology, Health Sciences Institute, Federal University of Bahia (UFBA), Salvador 40110-902, BrazilInstitute of Physics, University of São Paulo (IF-USP), São Paulo 05508-090, BrazilInstitute of Physics, University of São Paulo (IF-USP), São Paulo 05508-090, BrazilDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailability, besides acting over the main causes associated to AD. A thermo-responsive hydrogel is an interesting approach for facilitating the administration of the nanosystem via a nasal route, as well as for overcoming mucociliary clearance mechanisms. In light of this, MSN-CCM were dispersed in the hydrogel and evaluated through in vitro and in vivo assays. The MSNs and MSN-CCM were successfully characterized by physicochemical analysis and a high value of the CCM encapsulation efficiency (EE%, 87.70 ± 0.05) was achieved. The designed thermo-responsive hydrogel (HG) was characterized by rheology, texture profile analysis, and ex vivo mucoadhesion, showing excellent mechanical and mucoadhesive properties. Ex vivo permeation studies of MSN-CCM and HG@MSN-CCM showed high permeation values (12.46 ± 1.08 and 28.40 ± 1.88 μg cm<sup>−2</sup> of CCM, respectively) in porcine nasal mucosa. In vivo studies performed in a streptozotocin-induced AD model confirmed that HG@MSN-CCM reverted the cognitive deficit in mice, acting as a potential formulation in the treatment of AD.https://www.mdpi.com/1999-4923/14/9/1976brain disorderscurcuminoidsdrug delivery systemsmesoporous silica nanoparticlesneurodegenerative disorder |
| spellingShingle | Tais de Cassia Ribeiro Rafael Miguel Sábio Marcela Tavares Luiz Lucas Canto de Souza Bruno Fonseca-Santos Luis Carlos Cides da Silva Márcia Carvalho de Abreu Fantini Cleopatra da Silva Planeta Marlus Chorilli Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy Pharmaceutics brain disorders curcuminoids drug delivery systems mesoporous silica nanoparticles neurodegenerative disorder |
| title | Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy |
| title_full | Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy |
| title_fullStr | Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy |
| title_full_unstemmed | Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy |
| title_short | Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy |
| title_sort | curcumin loaded mesoporous silica nanoparticles dispersed in thermo responsive hydrogel as potential alzheimer disease therapy |
| topic | brain disorders curcuminoids drug delivery systems mesoporous silica nanoparticles neurodegenerative disorder |
| url | https://www.mdpi.com/1999-4923/14/9/1976 |
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