Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age
Conditions such as small for gestational age (SGA), which is defined as birthweight less than 10th percentile for gestational age can predispose to neurodevelopmental abnormalities compared to babies with normal birthweight. Fetal growth and birthweight depend on placental function, as this organ tr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1116770/full |
| _version_ | 1811167170106753024 |
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| author | Jorge Lopez-Tello Amanda N. Sferruzzi-Perri |
| author_facet | Jorge Lopez-Tello Amanda N. Sferruzzi-Perri |
| author_sort | Jorge Lopez-Tello |
| collection | DOAJ |
| description | Conditions such as small for gestational age (SGA), which is defined as birthweight less than 10th percentile for gestational age can predispose to neurodevelopmental abnormalities compared to babies with normal birthweight. Fetal growth and birthweight depend on placental function, as this organ transports substrates to the developing fetus and it acts as a source of endocrine factors, including steroids and prolactins that are required for fetal development and pregnancy maintenance. To advance our knowledge on the aetiology of fetal growth disorders, the vast majority of the research has been focused on studying the transport function of the placenta, leaving practically unexplored the contribution of placental hormones in the regulation of fetal growth. Here, using mice and natural variability in fetal growth within the litter, we compared fetuses that fell on or below the 10th percentile (classified as SGA) with those that had adequate weight for their gestational age (AGA). In particular, we compared placental endocrine metabolism and hormone production, as well as fetal brain weight and expression of developmental, growth and metabolic genes between SGA and AGA fetuses. We found that compared to AGA fetuses, SGA fetuses had lower placental efficiency and reduced capacity for placental production of hormones (e.g. steroidogenic gene Cyp17a1, prolactin Prl3a1, and pregnancy-specific glycoproteins Psg21). Brain weight was reduced in SGA fetuses, although this was proportional to the reduction in overall fetal size. The expression of glucose transporter 3 (Slc2a3) was reduced despite the abundance of AKT, FOXO and ERK proteins were similar. Developmental (Sv2b and Gabrg1) and microglia genes (Ier3), as well as the pregnancy-specific glycoprotein receptor (Cd9) were lower in the brain of SGA versus AGA fetuses. In this mouse model of SGA, our results therefore demonstrate that placental endocrine dysfunction is associated with changes in fetal growth and fetal brain development. |
| first_indexed | 2024-04-10T16:04:40Z |
| format | Article |
| id | doaj.art-4fa25124f37d4a68b51bf003cb3d6e04 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T16:04:40Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4fa25124f37d4a68b51bf003cb3d6e042023-02-10T05:49:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.11167701116770Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational ageJorge Lopez-TelloAmanda N. Sferruzzi-PerriConditions such as small for gestational age (SGA), which is defined as birthweight less than 10th percentile for gestational age can predispose to neurodevelopmental abnormalities compared to babies with normal birthweight. Fetal growth and birthweight depend on placental function, as this organ transports substrates to the developing fetus and it acts as a source of endocrine factors, including steroids and prolactins that are required for fetal development and pregnancy maintenance. To advance our knowledge on the aetiology of fetal growth disorders, the vast majority of the research has been focused on studying the transport function of the placenta, leaving practically unexplored the contribution of placental hormones in the regulation of fetal growth. Here, using mice and natural variability in fetal growth within the litter, we compared fetuses that fell on or below the 10th percentile (classified as SGA) with those that had adequate weight for their gestational age (AGA). In particular, we compared placental endocrine metabolism and hormone production, as well as fetal brain weight and expression of developmental, growth and metabolic genes between SGA and AGA fetuses. We found that compared to AGA fetuses, SGA fetuses had lower placental efficiency and reduced capacity for placental production of hormones (e.g. steroidogenic gene Cyp17a1, prolactin Prl3a1, and pregnancy-specific glycoproteins Psg21). Brain weight was reduced in SGA fetuses, although this was proportional to the reduction in overall fetal size. The expression of glucose transporter 3 (Slc2a3) was reduced despite the abundance of AKT, FOXO and ERK proteins were similar. Developmental (Sv2b and Gabrg1) and microglia genes (Ier3), as well as the pregnancy-specific glycoprotein receptor (Cd9) were lower in the brain of SGA versus AGA fetuses. In this mouse model of SGA, our results therefore demonstrate that placental endocrine dysfunction is associated with changes in fetal growth and fetal brain development.https://www.frontiersin.org/articles/10.3389/fendo.2023.1116770/fullplacentamousepregnancyprolactinpregnancy specific glycoproteinfetal growth |
| spellingShingle | Jorge Lopez-Tello Amanda N. Sferruzzi-Perri Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age Frontiers in Endocrinology placenta mouse pregnancy prolactin pregnancy specific glycoprotein fetal growth |
| title | Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age |
| title_full | Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age |
| title_fullStr | Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age |
| title_full_unstemmed | Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age |
| title_short | Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age |
| title_sort | characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age |
| topic | placenta mouse pregnancy prolactin pregnancy specific glycoprotein fetal growth |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1116770/full |
| work_keys_str_mv | AT jorgelopeztello characterizationofplacentalendocrinefunctionandfetalbraindevelopmentinamousemodelofsmallforgestationalage AT amandansferruzziperri characterizationofplacentalendocrinefunctionandfetalbraindevelopmentinamousemodelofsmallforgestationalage |