THE STUDY OF NANOSCALE IRON SUBSTANCE FOR THE PURPOSE OF DEVELOPING PHARMACEUTICAL CAPSULE DOSAGE FORM
Summary. The article is devoted to research on the development of a highly efficient pharmaceutical preparation of a new generation of iron-based nanoparticles for prevention and treatment of iron deficiency anemia and anemia of chronic disease. While the modern market of drugs represented a signifi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bogomolets National Medical University
2016-04-01
|
| Series: | Ukrainian Scientific Medical Youth Journal |
| Subjects: | |
| Online Access: | https://mmj.nmuofficial.com/index.php/journal/article/view/142 |
| Summary: | Summary. The article is devoted to research on the development of a highly efficient pharmaceutical preparation of a new generation of iron-based nanoparticles for prevention and treatment of iron deficiency anemia and anemia of chronic disease. While the modern market of drugs represented a significant arsenal of antianemic preparations, characterized by different iron content and the presence of auxiliary components that affect the pharmacokinetics of different dosage forms, but they do not fully meet the requirements of doctors and patients. We used the analytical, technological and biological research methods. The size and shape of the preparation of nanoparticles was determined by transmission electron microscopy. As the active ingredient of the pharmaceutical substance used iron ascorbic acid modified nanoparticles produced by chemical condensation in an aqueous medium by reduction of iron chloride (III). The dimensions of the iron oxide nanoparticles determines their physical, biological and pharmacological and toxicological properties. It is found that this substance - spherical iron nanoparticles of 40 nm. Based on experimental data, the pharmaceutical development determines the type of dosage form, provides an optimal therapeutic effect of drugs with minimal side effects, as well as ease of storage and use. As a result of studying the problems of the route of administration chosen type of dosage form and route of administration - the solid form of release in the form of capsules for oral administration. Complex study of physical and chemical characteristics of the drug at the design stage is used to justify the choice of method for assessing the efficacy and safety of the drug. The substance iron nanoparticles described in terms of biosafety in experiments in vitro and in vivo. Pharmaceutical development provides a scientific rationale for the selection of each of the auxiliary substances permitted for use in the manufacture of medicines. Excipients form a single active pharmaceutical ingredient in a system whose properties are determined and focused on providing the necessary therapeutic efficacy of the drug, so the next stage of research will focus on developing the optimal composition of hard gelatin capsules with the nanoparticles of iron. |
|---|---|
| ISSN: | 2786-6661 2786-667X |