Studies on the alternative evaluation of improving hypoxia tolerance function in health foods
ObjectiveTo explore the feasibility of new test methods for evaluation of improving hypoxia tolerance function in health food.MethodsHypoxia tolerance experiments were carried out on mice. The zebrafish hypoxia model was established， and the improvement of zebrafish hypoxia movement and erythrocytos...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | zho |
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The Editorial Office of Chinese Journal of Food Hygiene
2023-02-01
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| Series: | Zhongguo shipin weisheng zazhi |
| Subjects: | |
| Online Access: | http://www.zgspws.com/zgspwszz/article/abstract/202302005 |
| _version_ | 1797845191702347776 |
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| author | YANG Jun LIU Lei ZHANG Dachao SHEN Jiaqi HUANG Yanfeng TAO Gonghua HONG Xinyu |
| author_facet | YANG Jun LIU Lei ZHANG Dachao SHEN Jiaqi HUANG Yanfeng TAO Gonghua HONG Xinyu |
| author_sort | YANG Jun |
| collection | DOAJ |
| description | ObjectiveTo explore the feasibility of new test methods for evaluation of improving hypoxia tolerance function in health food.MethodsHypoxia tolerance experiments were carried out on mice. The zebrafish hypoxia model was established， and the improvement of zebrafish hypoxia movement and erythrocytosis were tested. A chemical hypoxia cell model was constructed with sodium disulfite， and cell activity and lactate dehydrogenase （LDH） activity were detected to verify their effect on hypoxia tolerance.ResultsCompared with normal control group， the hypoxia tolerance was improved in mice by health food sample. Compared with hypoxia model control groups， the sample improved zebrafish hypoxia， hypoxia-induced erycytosis， and alleviated the reduced cellular activity and increased LDH activity caused by cardiomyocyte hypoxia.ConclusionThe ability of the sample to improve hypoxia tolerance can be detected by three test systems in vitro as well as in vivo， and the introduction of alternative methods to animal testing for hypoxia tolerance tests is feasible. |
| first_indexed | 2024-04-09T17:34:49Z |
| format | Article |
| id | doaj.art-4fa3436414e54b80a3a3bc56060af35b |
| institution | Directory Open Access Journal |
| issn | 1004-8456 |
| language | zho |
| last_indexed | 2024-04-09T17:34:49Z |
| publishDate | 2023-02-01 |
| publisher | The Editorial Office of Chinese Journal of Food Hygiene |
| record_format | Article |
| series | Zhongguo shipin weisheng zazhi |
| spelling | doaj.art-4fa3436414e54b80a3a3bc56060af35b2023-04-18T02:30:22ZzhoThe Editorial Office of Chinese Journal of Food HygieneZhongguo shipin weisheng zazhi1004-84562023-02-0135217918310.13590/j.cjfh.2023.02.0051004-8456（2023）02-0179-05Studies on the alternative evaluation of improving hypoxia tolerance function in health foodsYANG Jun0LIU Lei1ZHANG Dachao2SHEN Jiaqi3HUANG Yanfeng4TAO Gonghua5HONG Xinyu6Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, ChinaShanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, ChinaChina Health Association, Beijing 100142, ChinaHunter Biotechnology, Inc., Zhejiang Hangzhou 310051, ChinaHunter Biotechnology, Inc., Zhejiang Hangzhou 310051, ChinaShanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, ChinaShanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, ChinaObjectiveTo explore the feasibility of new test methods for evaluation of improving hypoxia tolerance function in health food.MethodsHypoxia tolerance experiments were carried out on mice. The zebrafish hypoxia model was established， and the improvement of zebrafish hypoxia movement and erythrocytosis were tested. A chemical hypoxia cell model was constructed with sodium disulfite， and cell activity and lactate dehydrogenase （LDH） activity were detected to verify their effect on hypoxia tolerance.ResultsCompared with normal control group， the hypoxia tolerance was improved in mice by health food sample. Compared with hypoxia model control groups， the sample improved zebrafish hypoxia， hypoxia-induced erycytosis， and alleviated the reduced cellular activity and increased LDH activity caused by cardiomyocyte hypoxia.ConclusionThe ability of the sample to improve hypoxia tolerance can be detected by three test systems in vitro as well as in vivo， and the introduction of alternative methods to animal testing for hypoxia tolerance tests is feasible.http://www.zgspws.com/zgspwszz/article/abstract/202302005mousezebrafishcardiomyocyteshypoxia tolerance |
| spellingShingle | YANG Jun LIU Lei ZHANG Dachao SHEN Jiaqi HUANG Yanfeng TAO Gonghua HONG Xinyu Studies on the alternative evaluation of improving hypoxia tolerance function in health foods Zhongguo shipin weisheng zazhi mouse zebrafish cardiomyocytes hypoxia tolerance |
| title | Studies on the alternative evaluation of improving hypoxia tolerance function in health foods |
| title_full | Studies on the alternative evaluation of improving hypoxia tolerance function in health foods |
| title_fullStr | Studies on the alternative evaluation of improving hypoxia tolerance function in health foods |
| title_full_unstemmed | Studies on the alternative evaluation of improving hypoxia tolerance function in health foods |
| title_short | Studies on the alternative evaluation of improving hypoxia tolerance function in health foods |
| title_sort | studies on the alternative evaluation of improving hypoxia tolerance function in health foods |
| topic | mouse zebrafish cardiomyocytes hypoxia tolerance |
| url | http://www.zgspws.com/zgspwszz/article/abstract/202302005 |
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