A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer
Background/Aims Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigate...
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| Format: | Article |
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Korean Society of Gastrointestinal Endoscopy
2023-01-01
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| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2022-019.pdf |
| _version_ | 1797421318501564416 |
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| author | Tadayuki Takagi Mitsuru Sugimoto Hidemichi Imamura Yosuke Takahata Yuki Nakajima Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Yuko Hashimoto Goro Shibukawa Shigeru Marubashi Takuto Hikichi Hiromasa Ohira |
| author_facet | Tadayuki Takagi Mitsuru Sugimoto Hidemichi Imamura Yosuke Takahata Yuki Nakajima Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Yuko Hashimoto Goro Shibukawa Shigeru Marubashi Takuto Hikichi Hiromasa Ohira |
| author_sort | Tadayuki Takagi |
| collection | DOAJ |
| description | Background/Aims Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation in patients with UR-PC. Methods A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or EUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33) were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patients who underwent EUS-FNB and those who underwent EUS-FNA. Results No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwent EUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained using EUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariate analysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. Conclusions EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation. |
| first_indexed | 2024-03-09T07:15:10Z |
| format | Article |
| id | doaj.art-4fa443d125f94c0ea26a8a184129c414 |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T07:15:10Z |
| publishDate | 2023-01-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-4fa443d125f94c0ea26a8a184129c4142023-12-03T08:38:57ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432023-01-0156110711310.5946/ce.2022.0197660A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancerTadayuki Takagi0Mitsuru Sugimoto1Hidemichi Imamura2Yosuke Takahata3Yuki Nakajima4Rei Suzuki5Naoki Konno6Hiroyuki Asama7Yuki Sato8Hiroki Irie9Jun Nakamura10Mika Takasumi11Minami Hashimoto12Tsunetaka Kato13Ryoichiro Kobashi14Yuko Hashimoto15Goro Shibukawa16Shigeru Marubashi17Takuto Hikichi18Hiromasa Ohira19 Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, Ohtanishinouchi Hospital, Koriyama, Japan Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan Department of Hepato-Biliary-Pancreatic and Transplant Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, JapanBackground/Aims Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation in patients with UR-PC. Methods A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or EUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33) were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patients who underwent EUS-FNB and those who underwent EUS-FNA. Results No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwent EUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained using EUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariate analysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. Conclusions EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.http://www.e-ce.org/upload/pdf/ce-2022-019.pdfendoscopic ultrasound-guided fine-needle aspirationendoscopic ultrasound-guided fine-needle biopsyfranseen needlemicrosatellite instabilitypancreatic neoplasms |
| spellingShingle | Tadayuki Takagi Mitsuru Sugimoto Hidemichi Imamura Yosuke Takahata Yuki Nakajima Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Yuko Hashimoto Goro Shibukawa Shigeru Marubashi Takuto Hikichi Hiromasa Ohira A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer Clinical Endoscopy endoscopic ultrasound-guided fine-needle aspiration endoscopic ultrasound-guided fine-needle biopsy franseen needle microsatellite instability pancreatic neoplasms |
| title | A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer |
| title_full | A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer |
| title_fullStr | A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer |
| title_full_unstemmed | A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer |
| title_short | A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer |
| title_sort | multicenter comparative study of endoscopic ultrasound guided fine needle biopsy using a franseen needle versus conventional endoscopic ultrasound guided fine needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer |
| topic | endoscopic ultrasound-guided fine-needle aspiration endoscopic ultrasound-guided fine-needle biopsy franseen needle microsatellite instability pancreatic neoplasms |
| url | http://www.e-ce.org/upload/pdf/ce-2022-019.pdf |
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