Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing
Sensory processing in the cortex should integrate inputs arriving from receptive fields located on both sides of the body. This role could be played by the corpus callosum through precise projections between both hemispheres. However, different studies suggest that cholinergic projections from the b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnana.2018.00005/full |
| _version_ | 1818931665937891328 |
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| author | Irene Chaves-Coira Margarita L. Rodrigo-Angulo Angel Nuñez |
| author_facet | Irene Chaves-Coira Margarita L. Rodrigo-Angulo Angel Nuñez |
| author_sort | Irene Chaves-Coira |
| collection | DOAJ |
| description | Sensory processing in the cortex should integrate inputs arriving from receptive fields located on both sides of the body. This role could be played by the corpus callosum through precise projections between both hemispheres. However, different studies suggest that cholinergic projections from the basal forebrain (BF) could also contribute to the synchronization and integration of cortical activities. Using tracer injections and optogenetic techniques in transgenic mice, we investigated whether the BF cells project bilaterally to sensory cortical areas, and have provided anatomical evidence to support a modulatory role for the cholinergic projections in sensory integration. Application of the retrograde tracer Fluor-Gold or Fast Blue in both hemispheres of the primary somatosensory (S1), auditory or visual cortical areas showed labeled neurons in the ipsi- and contralateral areas of the diagonal band of Broca and substantia innominata. The nucleus basalis magnocellularis only showed ipsilateral projections to the cortex. Optogenetic stimulation of the horizontal limb of the diagonal band of Broca facilitated whisker responses in the S1 cortex of both hemispheres through activation of muscarinic cholinergic receptors and this effect was diminished by atropine injection. In conclusion, our findings have revealed that specific areas of the BF project bilaterally to sensory cortices and may contribute to the coordination of neuronal activity on both hemispheres. |
| first_indexed | 2024-12-20T04:20:13Z |
| format | Article |
| id | doaj.art-4fa46ed9d382455598a90eeff831f5d0 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-20T04:20:13Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-4fa46ed9d382455598a90eeff831f5d02022-12-21T19:53:39ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292018-01-011210.3389/fnana.2018.00005309415Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory ProcessingIrene Chaves-Coira0Margarita L. Rodrigo-Angulo1Angel Nuñez2epartment of Anatomy, Histology and Neuroscience, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spainepartment of Anatomy, Histology and Neuroscience, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spainepartment of Anatomy, Histology and Neuroscience, School of Medicine, Universidad Autonoma de Madrid, Madrid, SpainSensory processing in the cortex should integrate inputs arriving from receptive fields located on both sides of the body. This role could be played by the corpus callosum through precise projections between both hemispheres. However, different studies suggest that cholinergic projections from the basal forebrain (BF) could also contribute to the synchronization and integration of cortical activities. Using tracer injections and optogenetic techniques in transgenic mice, we investigated whether the BF cells project bilaterally to sensory cortical areas, and have provided anatomical evidence to support a modulatory role for the cholinergic projections in sensory integration. Application of the retrograde tracer Fluor-Gold or Fast Blue in both hemispheres of the primary somatosensory (S1), auditory or visual cortical areas showed labeled neurons in the ipsi- and contralateral areas of the diagonal band of Broca and substantia innominata. The nucleus basalis magnocellularis only showed ipsilateral projections to the cortex. Optogenetic stimulation of the horizontal limb of the diagonal band of Broca facilitated whisker responses in the S1 cortex of both hemispheres through activation of muscarinic cholinergic receptors and this effect was diminished by atropine injection. In conclusion, our findings have revealed that specific areas of the BF project bilaterally to sensory cortices and may contribute to the coordination of neuronal activity on both hemispheres.http://journal.frontiersin.org/article/10.3389/fnana.2018.00005/fulldiagonal band of Brocabasal magnocellular nucleuscholinergic neuronssomatosensory evoked potentialoptogenetic stimulationmouse |
| spellingShingle | Irene Chaves-Coira Margarita L. Rodrigo-Angulo Angel Nuñez Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing Frontiers in Neuroanatomy diagonal band of Broca basal magnocellular nucleus cholinergic neurons somatosensory evoked potential optogenetic stimulation mouse |
| title | Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing |
| title_full | Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing |
| title_fullStr | Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing |
| title_full_unstemmed | Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing |
| title_short | Bilateral Pathways from the Basal Forebrain to Sensory Cortices May Contribute to Synchronous Sensory Processing |
| title_sort | bilateral pathways from the basal forebrain to sensory cortices may contribute to synchronous sensory processing |
| topic | diagonal band of Broca basal magnocellular nucleus cholinergic neurons somatosensory evoked potential optogenetic stimulation mouse |
| url | http://journal.frontiersin.org/article/10.3389/fnana.2018.00005/full |
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