Regulatory effect of anisotropic structure on cardiomyocyte maturation
Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to the limited regenerative capacity of the adult heart, treatments based on human pluripotent stem cells (hPSCs) have become the focus of a great deal of research. Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Innovation Publishing House Pte. Ltd.
2023-07-01
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| Series: | STEMedicine |
| Subjects: | |
| Online Access: | https://stemedicine.org/index.php/stem/article/view/179 |
| _version_ | 1827908975504392192 |
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| author | Yue Xu Miao Xiao Xiaoyun Li Ziyun Jiang |
| author_facet | Yue Xu Miao Xiao Xiaoyun Li Ziyun Jiang |
| author_sort | Yue Xu |
| collection | DOAJ |
| description |
Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to the limited regenerative capacity of the adult heart, treatments based on human pluripotent stem cells (hPSCs) have become the focus of a great deal of research. Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) can provide an ideal cell source for CVD model construction, cardiac tissue repair, and drug cardiotoxicology research. However, the immaturity of hPSC-CMs seriously restricts its clinical application. The maturation of cardiomyocytes depends on the orderly arrangement of myofilaments and the increase of the expression of connexin, so the geometric regulation of bioengineering substrate is one of the keys to the maturation of engineered myocardial tissue. This review focuses on the key indicators of anisotropic structures provided by biomaterials to improve the maturation characteristics of cardiomyocytes, so as to promote the maturation of cardiomyocytes, and looks forward to the development direction in this field.
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| first_indexed | 2024-03-13T01:29:58Z |
| format | Article |
| id | doaj.art-4fa54d6d2dc3431393d44c4dd827d043 |
| institution | Directory Open Access Journal |
| issn | 2705-1188 |
| language | English |
| last_indexed | 2024-03-13T01:29:58Z |
| publishDate | 2023-07-01 |
| publisher | Innovation Publishing House Pte. Ltd. |
| record_format | Article |
| series | STEMedicine |
| spelling | doaj.art-4fa54d6d2dc3431393d44c4dd827d0432023-07-04T08:04:32ZengInnovation Publishing House Pte. Ltd.STEMedicine2705-11882023-07-014310.37175/stemedicine.v4i3.179Regulatory effect of anisotropic structure on cardiomyocyte maturationYue Xu0Miao Xiao1Xiaoyun Li2Ziyun Jiang3Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, ChinaInstitute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, ChinaInstitute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, ChinaInstitute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, China Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to the limited regenerative capacity of the adult heart, treatments based on human pluripotent stem cells (hPSCs) have become the focus of a great deal of research. Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) can provide an ideal cell source for CVD model construction, cardiac tissue repair, and drug cardiotoxicology research. However, the immaturity of hPSC-CMs seriously restricts its clinical application. The maturation of cardiomyocytes depends on the orderly arrangement of myofilaments and the increase of the expression of connexin, so the geometric regulation of bioengineering substrate is one of the keys to the maturation of engineered myocardial tissue. This review focuses on the key indicators of anisotropic structures provided by biomaterials to improve the maturation characteristics of cardiomyocytes, so as to promote the maturation of cardiomyocytes, and looks forward to the development direction in this field. https://stemedicine.org/index.php/stem/article/view/179Cardiovascular diseasehuman pluripotent stem cellscardiomyocytesbioengineeringanisotropic structure |
| spellingShingle | Yue Xu Miao Xiao Xiaoyun Li Ziyun Jiang Regulatory effect of anisotropic structure on cardiomyocyte maturation STEMedicine Cardiovascular disease human pluripotent stem cells cardiomyocytes bioengineering anisotropic structure |
| title | Regulatory effect of anisotropic structure on cardiomyocyte maturation |
| title_full | Regulatory effect of anisotropic structure on cardiomyocyte maturation |
| title_fullStr | Regulatory effect of anisotropic structure on cardiomyocyte maturation |
| title_full_unstemmed | Regulatory effect of anisotropic structure on cardiomyocyte maturation |
| title_short | Regulatory effect of anisotropic structure on cardiomyocyte maturation |
| title_sort | regulatory effect of anisotropic structure on cardiomyocyte maturation |
| topic | Cardiovascular disease human pluripotent stem cells cardiomyocytes bioengineering anisotropic structure |
| url | https://stemedicine.org/index.php/stem/article/view/179 |
| work_keys_str_mv | AT yuexu regulatoryeffectofanisotropicstructureoncardiomyocytematuration AT miaoxiao regulatoryeffectofanisotropicstructureoncardiomyocytematuration AT xiaoyunli regulatoryeffectofanisotropicstructureoncardiomyocytematuration AT ziyunjiang regulatoryeffectofanisotropicstructureoncardiomyocytematuration |