Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou
Abstract Background Acute respiratory infections are a common disease in children with high mortality and morbidity. Multiple pathogens can cause acute respiratory infections. A 2-year survey of hospitalized children was conducted to understand the epidemic situation, seasonal spread of pathogens an...
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| Format: | Article |
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BMC
2020-08-01
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| Series: | Virology Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12985-020-01380-4 |
| _version_ | 1818190469103878144 |
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| author | Min Gao Xing Yao Wei Mao Cuifen Shen Zongxin Zhang Qiuling Huang Dawei Cui Haiyan Sun Weihua Zou |
| author_facet | Min Gao Xing Yao Wei Mao Cuifen Shen Zongxin Zhang Qiuling Huang Dawei Cui Haiyan Sun Weihua Zou |
| author_sort | Min Gao |
| collection | DOAJ |
| description | Abstract Background Acute respiratory infections are a common disease in children with high mortality and morbidity. Multiple pathogens can cause acute respiratory infections. A 2-year survey of hospitalized children was conducted to understand the epidemic situation, seasonal spread of pathogens and the improvement of clinical diagnosis, treatment and prevention of disease in Huzhou, China. Methods From September 2017 to August 2019, 3121 nasopharyngeal swabs from hospitalized children with acute respiratory infections were collected, and real-time PCR was used to detect various pathogens. Then, pathogen profiles, frequency and seasonality were analyzed. Results Of the 3121 specimens, 14.45% (451/3121) were positive for at least one pathogen. Of the single-pathogen infections, RSV (45.61%, 182/399) was the most frequent pathogen, followed by PIVs (14.79%, 59/399), ADV (14.54%, 58/399), MP (10.78%, 43/399), and IAV (5.26%, 21/399). Of the 52 coinfections, RSV + PIVs viruses were predominantly identified and accounted for 40.38% (21/52) of cases. RSV was the most frequent pathogen in all four groups. The highest positive rate of the pathogens occurred in the winter (21.26%), followed by autumn (14.98%), the summer (14.11%) and the spring (12.25%). Conclusion Viruses are the main pathogens in hospitalized children with acute respiratory infections in Huzhou city, Zhejiang Province, China. Among the pathogens, RSV had the highest detection rate, and MP is also a common pathogen among children with acute respiratory infections. This study provided a better understanding of the distribution of pathogens in children of different ages and seasons, which is conducive to the development of more reasonable treatment strategies and prevention and control measures. |
| first_indexed | 2024-12-11T23:59:12Z |
| format | Article |
| id | doaj.art-4fa7450079b14e99847aa990ed2776f3 |
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| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-11T23:59:12Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-4fa7450079b14e99847aa990ed2776f32022-12-22T00:45:16ZengBMCVirology Journal1743-422X2020-08-011711810.1186/s12985-020-01380-4Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in HuzhouMin Gao0Xing Yao1Wei Mao2Cuifen Shen3Zongxin Zhang4Qiuling Huang5Dawei Cui6Haiyan Sun7Weihua Zou8Department of Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityHepatobiliary and Pancreatic Surgery, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityDepartment of Respiratory Diseases, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityDepartment of Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityDepartment of Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityDepartment of Pediatrics, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityDepartment of Blood Transfusion, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Clinical Laboratory, Shaoxing Second HospitalDepartment of Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital Huzhou UniversityAbstract Background Acute respiratory infections are a common disease in children with high mortality and morbidity. Multiple pathogens can cause acute respiratory infections. A 2-year survey of hospitalized children was conducted to understand the epidemic situation, seasonal spread of pathogens and the improvement of clinical diagnosis, treatment and prevention of disease in Huzhou, China. Methods From September 2017 to August 2019, 3121 nasopharyngeal swabs from hospitalized children with acute respiratory infections were collected, and real-time PCR was used to detect various pathogens. Then, pathogen profiles, frequency and seasonality were analyzed. Results Of the 3121 specimens, 14.45% (451/3121) were positive for at least one pathogen. Of the single-pathogen infections, RSV (45.61%, 182/399) was the most frequent pathogen, followed by PIVs (14.79%, 59/399), ADV (14.54%, 58/399), MP (10.78%, 43/399), and IAV (5.26%, 21/399). Of the 52 coinfections, RSV + PIVs viruses were predominantly identified and accounted for 40.38% (21/52) of cases. RSV was the most frequent pathogen in all four groups. The highest positive rate of the pathogens occurred in the winter (21.26%), followed by autumn (14.98%), the summer (14.11%) and the spring (12.25%). Conclusion Viruses are the main pathogens in hospitalized children with acute respiratory infections in Huzhou city, Zhejiang Province, China. Among the pathogens, RSV had the highest detection rate, and MP is also a common pathogen among children with acute respiratory infections. This study provided a better understanding of the distribution of pathogens in children of different ages and seasons, which is conducive to the development of more reasonable treatment strategies and prevention and control measures.http://link.springer.com/article/10.1186/s12985-020-01380-4Acute respiratory infectionsHospitalized childrenEtiologyHuzhou |
| spellingShingle | Min Gao Xing Yao Wei Mao Cuifen Shen Zongxin Zhang Qiuling Huang Dawei Cui Haiyan Sun Weihua Zou Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou Virology Journal Acute respiratory infections Hospitalized children Etiology Huzhou |
| title | Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou |
| title_full | Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou |
| title_fullStr | Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou |
| title_full_unstemmed | Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou |
| title_short | Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou |
| title_sort | etiological analysis of virus mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in huzhou |
| topic | Acute respiratory infections Hospitalized children Etiology Huzhou |
| url | http://link.springer.com/article/10.1186/s12985-020-01380-4 |
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