Establishment of a co-culture system using Escherichia coli and Pichia pastoris (Komagataella phaffii) for valuable alkaloid production

Establishment of a co-culture system using Escherichia coli and Pichia pastoris (Komagataella phaffii) for valuable alkaloid production

Abstract Background Plants produce a variety of specialized metabolites, many of which are used in pharmaceutical industries as raw materials. However, certain metabolites may be produced at markedly low concentrations in plants. This problem has been overcome through metabolic engineering in recent...

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Bibliographic Details
Main Authors: Miya Urui, Yasuyuki Yamada, Yoshito Ikeda, Akira Nakagawa, Fumihiko Sato, Hiromichi Minami, Nobukazu Shitan
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Microbial Cell Factories
Subjects:
Benzylisoquinoline alkaloid
Stylopine
Reticuline
Escherichia coli
Pichia pastoris
Metabolic engineering
Online Access:https://doi.org/10.1186/s12934-021-01687-z

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