STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke

STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke

Abstract Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption of the surviving neuronal network and related brain function. Unfortunately, there...

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Bibliographic Details
Main Authors: Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi, Hong Liao
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Microglia
Synapse phagocytosis
STING
STAT1
Online Access:https://doi.org/10.1186/s12974-024-03086-8

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