Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan
Objectives: The use of assisted reproductive technology (ART) has increased rapidly in Taiwan. The purpose of this study is to discuss the risks of low birth weight, preterm birth, and birth defect for children conceived by assisted reproductive technology in Taiwan.Methods: Both National ART report...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-03-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00087/full |
| _version_ | 1818409991015497728 |
|---|---|
| author | Heng-Yu Chang Wuh-Liang Hwu Ching-Hui Chen Ching-Hui Chen Chun-Yin Hou Wei Cheng Wei Cheng Wei Cheng |
| author_facet | Heng-Yu Chang Wuh-Liang Hwu Ching-Hui Chen Ching-Hui Chen Chun-Yin Hou Wei Cheng Wei Cheng Wei Cheng |
| author_sort | Heng-Yu Chang |
| collection | DOAJ |
| description | Objectives: The use of assisted reproductive technology (ART) has increased rapidly in Taiwan. The purpose of this study is to discuss the risks of low birth weight, preterm birth, and birth defect for children conceived by assisted reproductive technology in Taiwan.Methods: Both National ART report database and National birth reports were obtained from the Health Promotion Administration in the Ministry of Health and Welfare in Taiwan. The cohort included live births (n = 1,405,625) and children conceived by ART (n = 50,988/172,818 cycles) from 2011 to 2017. The prevalence of low birth weight, preterm birth, and birth defect were compared between the ART and natural pregnancy groups.Results: Children conceived by ART displayed a higher rate of low birth weight as compared to those in the natural pregnancy group (p < 0.001), even when analyses were restricted to singleton births (p < 0.001). A higher rate of preterm birth (p < 0.001) was also observed in children conceived by ART even when analyses were restricted to singleton births (p < 0.05). A significant increased rate of birth defects was noted from children conceived by ART (p < 0.05).Conclusions: With the increasing need for and use of ART-conceptions, the likelihood of risks induced or related to Assistant Reproductive Technology (ART) has drawn considerable attention in recent years. Taiwan, as one of the leading countries with outstanding ART performances and modern medical care, the result of the current study suggests that further consideration and tighter regulations and policy are needed with regard to the use of ART. |
| first_indexed | 2024-12-14T10:08:25Z |
| format | Article |
| id | doaj.art-4faacb508708419190832a7a74c537ec |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-14T10:08:25Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-4faacb508708419190832a7a74c537ec2022-12-21T23:07:05ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-03-01810.3389/fped.2020.00087517090Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in TaiwanHeng-Yu Chang0Wuh-Liang Hwu1Ching-Hui Chen2Ching-Hui Chen3Chun-Yin Hou4Wei Cheng5Wei Cheng6Wei Cheng7Department of Biochemistry and Molecular Cell Biology, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, TaiwanDivision of Reproductive Medicine, Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Family Medicine, Taipei City Hospital, Taipei, TaiwanDepartment of Pathology, Kee-Lung Hospital, Ministry of Health and Welfare, Keelung City, TaiwanDepartment of Nursing, Ching Kuo Institute of Management and Health, Keelung City, TaiwanSchool of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, TaiwanObjectives: The use of assisted reproductive technology (ART) has increased rapidly in Taiwan. The purpose of this study is to discuss the risks of low birth weight, preterm birth, and birth defect for children conceived by assisted reproductive technology in Taiwan.Methods: Both National ART report database and National birth reports were obtained from the Health Promotion Administration in the Ministry of Health and Welfare in Taiwan. The cohort included live births (n = 1,405,625) and children conceived by ART (n = 50,988/172,818 cycles) from 2011 to 2017. The prevalence of low birth weight, preterm birth, and birth defect were compared between the ART and natural pregnancy groups.Results: Children conceived by ART displayed a higher rate of low birth weight as compared to those in the natural pregnancy group (p < 0.001), even when analyses were restricted to singleton births (p < 0.001). A higher rate of preterm birth (p < 0.001) was also observed in children conceived by ART even when analyses were restricted to singleton births (p < 0.05). A significant increased rate of birth defects was noted from children conceived by ART (p < 0.05).Conclusions: With the increasing need for and use of ART-conceptions, the likelihood of risks induced or related to Assistant Reproductive Technology (ART) has drawn considerable attention in recent years. Taiwan, as one of the leading countries with outstanding ART performances and modern medical care, the result of the current study suggests that further consideration and tighter regulations and policy are needed with regard to the use of ART.https://www.frontiersin.org/article/10.3389/fped.2020.00087/fullassisted reproductive technologylower birth weightpreterm birthbirth defectslive births |
| spellingShingle | Heng-Yu Chang Wuh-Liang Hwu Ching-Hui Chen Ching-Hui Chen Chun-Yin Hou Wei Cheng Wei Cheng Wei Cheng Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan Frontiers in Pediatrics assisted reproductive technology lower birth weight preterm birth birth defects live births |
| title | Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan |
| title_full | Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan |
| title_fullStr | Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan |
| title_full_unstemmed | Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan |
| title_short | Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan |
| title_sort | children conceived by assisted reproductive technology prone to low birth weight preterm birth and birth defects a cohort review of more than 50 000 live births during 2011 2017 in taiwan |
| topic | assisted reproductive technology lower birth weight preterm birth birth defects live births |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00087/full |
| work_keys_str_mv | AT hengyuchang childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT wuhlianghwu childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT chinghuichen childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT chinghuichen childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT chunyinhou childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT weicheng childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT weicheng childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan AT weicheng childrenconceivedbyassistedreproductivetechnologypronetolowbirthweightpretermbirthandbirthdefectsacohortreviewofmorethan50000livebirthsduring20112017intaiwan |