The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways
The lysophosphatidic acid 3 receptor (LPA<sub>3</sub>) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA<sub>3</sub> receptor is...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6704 |
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| author | Karina Helivier Solís M. Teresa Romero-Ávila Alejandro Guzmán-Silva J. Adolfo García-Sáinz |
| author_facet | Karina Helivier Solís M. Teresa Romero-Ávila Alejandro Guzmán-Silva J. Adolfo García-Sáinz |
| author_sort | Karina Helivier Solís |
| collection | DOAJ |
| description | The lysophosphatidic acid 3 receptor (LPA<sub>3</sub>) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA<sub>3</sub> receptor is a crucial element for defining its roles in health and disease. This review describes what is known about the signaling pathways activated in terms of its various actions. Next, we review knowledge on the structure of the LPA<sub>3</sub> receptor, the domains found, and the roles that the latter might play in ligand recognition, signaling, and cellular localization. Currently, there is some information on the action of LPA<sub>3</sub> in different cells and whole organisms, but very little is known about the regulation of its function. Areas in which there is a gap in our knowledge are indicated in order to further stimulate experimental work on this receptor and on other members of the LPA receptor family. We are convinced that knowledge on how this receptor is activated, the signaling pathways employed and how the receptor internalization and desensitization are controlled will help design new therapeutic interventions for treating diseases in which the LPA<sub>3</sub> receptor is implicated. |
| first_indexed | 2024-03-10T10:09:37Z |
| format | Article |
| id | doaj.art-4fab11d07e0d4fa2bcc2bcfe35d2d64f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:09:37Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4fab11d07e0d4fa2bcc2bcfe35d2d64f2023-11-22T01:17:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213670410.3390/ijms22136704The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling PathwaysKarina Helivier Solís0M. Teresa Romero-Ávila1Alejandro Guzmán-Silva2J. Adolfo García-Sáinz3Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad de México CP 04510, MexicoDepartamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad de México CP 04510, MexicoDepartamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad de México CP 04510, MexicoDepartamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad de México CP 04510, MexicoThe lysophosphatidic acid 3 receptor (LPA<sub>3</sub>) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA<sub>3</sub> receptor is a crucial element for defining its roles in health and disease. This review describes what is known about the signaling pathways activated in terms of its various actions. Next, we review knowledge on the structure of the LPA<sub>3</sub> receptor, the domains found, and the roles that the latter might play in ligand recognition, signaling, and cellular localization. Currently, there is some information on the action of LPA<sub>3</sub> in different cells and whole organisms, but very little is known about the regulation of its function. Areas in which there is a gap in our knowledge are indicated in order to further stimulate experimental work on this receptor and on other members of the LPA receptor family. We are convinced that knowledge on how this receptor is activated, the signaling pathways employed and how the receptor internalization and desensitization are controlled will help design new therapeutic interventions for treating diseases in which the LPA<sub>3</sub> receptor is implicated.https://www.mdpi.com/1422-0067/22/13/6704lysophosphatidic acid 3 receptorLPA<sub>3</sub>receptor phosphorylationGRKPKClysophosphatidic acid |
| spellingShingle | Karina Helivier Solís M. Teresa Romero-Ávila Alejandro Guzmán-Silva J. Adolfo García-Sáinz The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways International Journal of Molecular Sciences lysophosphatidic acid 3 receptor LPA<sub>3</sub> receptor phosphorylation GRK PKC lysophosphatidic acid |
| title | The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways |
| title_full | The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways |
| title_fullStr | The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways |
| title_full_unstemmed | The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways |
| title_short | The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways |
| title_sort | lpa sub 3 sub receptor regulation and activation of signaling pathways |
| topic | lysophosphatidic acid 3 receptor LPA<sub>3</sub> receptor phosphorylation GRK PKC lysophosphatidic acid |
| url | https://www.mdpi.com/1422-0067/22/13/6704 |
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