Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation
The data herein is related to the research article entitled “Microbiota-inducible innate immune siderophore binding protein Lipocalin 2 is critical for intestinal homeostasis” (Singh et al., 2016) [1]. In the present article, we monitored dextran sodium sulfate (DSS)-induced colitis development upon...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916304152 |
| _version_ | 1830301758304288768 |
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| author | Piu Saha Vishal Singh Xia Xiao Beng San Yeoh Matam Vijay-Kumar |
| author_facet | Piu Saha Vishal Singh Xia Xiao Beng San Yeoh Matam Vijay-Kumar |
| author_sort | Piu Saha |
| collection | DOAJ |
| description | The data herein is related to the research article entitled “Microbiota-inducible innate immune siderophore binding protein Lipocalin 2 is critical for intestinal homeostasis” (Singh et al., 2016) [1]. In the present article, we monitored dextran sodium sulfate (DSS)-induced colitis development upon Lipocalin 2 (Lcn2) neutralization, and examined the survival of Lcn2 deficient (Lcn2KO) mice and their WT littermates upon DSS challenge. To dissect the relative contribution of immune and non-immune cells-derived Lcn2 in mediating protection against gut inflammation, we generated respective bone marrow chimera and evaluated their susceptibility to IL-10 receptor neutralization-induced chronic colitis.Neutralization of Lcn2 in WT mice resulted in exacerbated DSS-induced colitis. Notably, mice lacking Lcn2 exhibited 100% mortality whereas only 20% mortality was observed in WT mice upon DSS challenge. Further, data from bone marrow chimera showed that immune cell-derived Lcn2 is the major contributor in conferring protection against colitis. Keywords: Siderocalin, Gut microbiota, Inflammatory bowel disease, Bone marrow chimeras, Colitis |
| first_indexed | 2024-12-19T08:55:25Z |
| format | Article |
| id | doaj.art-4fae316964b045f1a2e6de53eb7bf866 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-19T08:55:25Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-4fae316964b045f1a2e6de53eb7bf8662022-12-21T20:28:37ZengElsevierData in Brief2352-34092016-09-018812816Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammationPiu Saha0Vishal Singh1Xia Xiao2Beng San Yeoh3Matam Vijay-Kumar4Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, United StatesDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, United StatesDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, United StatesDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, United StatesDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, United States; Department of Medicine, The Pennsylvania State University Medical Center, Hershey, PA 17033, United States; Corresponding author at: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, United States. Fax: +1 814 863 6103.The data herein is related to the research article entitled “Microbiota-inducible innate immune siderophore binding protein Lipocalin 2 is critical for intestinal homeostasis” (Singh et al., 2016) [1]. In the present article, we monitored dextran sodium sulfate (DSS)-induced colitis development upon Lipocalin 2 (Lcn2) neutralization, and examined the survival of Lcn2 deficient (Lcn2KO) mice and their WT littermates upon DSS challenge. To dissect the relative contribution of immune and non-immune cells-derived Lcn2 in mediating protection against gut inflammation, we generated respective bone marrow chimera and evaluated their susceptibility to IL-10 receptor neutralization-induced chronic colitis.Neutralization of Lcn2 in WT mice resulted in exacerbated DSS-induced colitis. Notably, mice lacking Lcn2 exhibited 100% mortality whereas only 20% mortality was observed in WT mice upon DSS challenge. Further, data from bone marrow chimera showed that immune cell-derived Lcn2 is the major contributor in conferring protection against colitis. Keywords: Siderocalin, Gut microbiota, Inflammatory bowel disease, Bone marrow chimeras, Colitishttp://www.sciencedirect.com/science/article/pii/S2352340916304152 |
| spellingShingle | Piu Saha Vishal Singh Xia Xiao Beng San Yeoh Matam Vijay-Kumar Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation Data in Brief |
| title | Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation |
| title_full | Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation |
| title_fullStr | Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation |
| title_full_unstemmed | Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation |
| title_short | Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation |
| title_sort | data on importance of hematopoietic cell derived lipocalin 2 against gut inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916304152 |
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