Natural product-based pharmacological studies for neurological disorders
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in pr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1011740/full |
| _version_ | 1797984352167002112 |
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| author | Vivek Puri Neha Kanojia Ameya Sharma Kampanart Huanbutta Divya Dheer Tanikan Sangnim |
| author_facet | Vivek Puri Neha Kanojia Ameya Sharma Kampanart Huanbutta Divya Dheer Tanikan Sangnim |
| author_sort | Vivek Puri |
| collection | DOAJ |
| description | Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease. |
| first_indexed | 2024-04-11T07:00:59Z |
| format | Article |
| id | doaj.art-4faef42194d6449da30f22fc1a7882b8 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T07:00:59Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4faef42194d6449da30f22fc1a7882b82022-12-22T04:38:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10117401011740Natural product-based pharmacological studies for neurological disordersVivek Puri0Neha Kanojia1Ameya Sharma2Kampanart Huanbutta3Divya Dheer4Tanikan Sangnim5Chitkara School of Pharmacy, Chitkara University, Baddi, Himachal Pradesh, IndiaChitkara School of Pharmacy, Chitkara University, Baddi, Himachal Pradesh, IndiaChitkara School of Pharmacy, Chitkara University, Baddi, Himachal Pradesh, IndiaSchool of Pharmacy, Eastern Asia University, Rangsit, Pathum Thani, ThailandChitkara School of Pharmacy, Chitkara University, Baddi, Himachal Pradesh, IndiaFaculty of Pharmaceutical Sciences, Burapha University, Muang, Chon Buri, ThailandCentral nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease.https://www.frontiersin.org/articles/10.3389/fphar.2022.1011740/fullnatural productsneurological disordersclinical researchbioinformatic toolstranslational research |
| spellingShingle | Vivek Puri Neha Kanojia Ameya Sharma Kampanart Huanbutta Divya Dheer Tanikan Sangnim Natural product-based pharmacological studies for neurological disorders Frontiers in Pharmacology natural products neurological disorders clinical research bioinformatic tools translational research |
| title | Natural product-based pharmacological studies for neurological disorders |
| title_full | Natural product-based pharmacological studies for neurological disorders |
| title_fullStr | Natural product-based pharmacological studies for neurological disorders |
| title_full_unstemmed | Natural product-based pharmacological studies for neurological disorders |
| title_short | Natural product-based pharmacological studies for neurological disorders |
| title_sort | natural product based pharmacological studies for neurological disorders |
| topic | natural products neurological disorders clinical research bioinformatic tools translational research |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1011740/full |
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