The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations
<p>Abstract</p> <p>Recently, inter-population comparisons of allele frequencies to detect past selection haven gained popularity. Data from genome-wide scans are used to detect the number and position of genes that have responded to unknown selection pressures in natural population...
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| Format: | Article |
| Language: | deu |
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BMC
2005-12-01
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| Series: | Genetics Selection Evolution |
| Subjects: | |
| Online Access: | http://www.gsejournal.org/content/38/1/3 |
| _version_ | 1830211902951653376 |
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| author | De Kovel Carolien |
| author_facet | De Kovel Carolien |
| author_sort | De Kovel Carolien |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Recently, inter-population comparisons of allele frequencies to detect past selection haven gained popularity. Data from genome-wide scans are used to detect the number and position of genes that have responded to unknown selection pressures in natural populations, or known selection pressures in experimental lines. Yet, the limitations and possibilities of these methods have not been well studied. In this paper, the objectives were (1) to investigate the distance over which a signal of directional selection is detectable under various scenarios, and (2) to study the power of the method depending on the properties of the used markers, for both natural populations and experimental set-ups. A combination of recurrence equations and simulations was used. The results show that intermediate strength selection on new mutations can be detected with a marker spacing of about 0.5 cM in large natural populations, 200 to 400 generations after the divergence of subpopulations. In experimental situations, only strong selection will be detectable, while markers can be spaced a few cM apart. Adaptation from standing variation in the base population will be hard to detect, though some solutions are presented for experimental designs.</p> |
| first_indexed | 2024-12-18T05:53:04Z |
| format | Article |
| id | doaj.art-4faf5b962cca42dcb6c37abd1e16d394 |
| institution | Directory Open Access Journal |
| issn | 0999-193X 1297-9686 |
| language | deu |
| last_indexed | 2024-12-18T05:53:04Z |
| publishDate | 2005-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Genetics Selection Evolution |
| spelling | doaj.art-4faf5b962cca42dcb6c37abd1e16d3942022-12-21T21:18:52ZdeuBMCGenetics Selection Evolution0999-193X1297-96862005-12-0138132310.1186/1297-9686-38-1-3The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situationsDe Kovel Carolien<p>Abstract</p> <p>Recently, inter-population comparisons of allele frequencies to detect past selection haven gained popularity. Data from genome-wide scans are used to detect the number and position of genes that have responded to unknown selection pressures in natural populations, or known selection pressures in experimental lines. Yet, the limitations and possibilities of these methods have not been well studied. In this paper, the objectives were (1) to investigate the distance over which a signal of directional selection is detectable under various scenarios, and (2) to study the power of the method depending on the properties of the used markers, for both natural populations and experimental set-ups. A combination of recurrence equations and simulations was used. The results show that intermediate strength selection on new mutations can be detected with a marker spacing of about 0.5 cM in large natural populations, 200 to 400 generations after the divergence of subpopulations. In experimental situations, only strong selection will be detectable, while markers can be spaced a few cM apart. Adaptation from standing variation in the base population will be hard to detect, though some solutions are presented for experimental designs.</p>http://www.gsejournal.org/content/38/1/3artificial selectionhitchhikinglinkage disequilibriumnatural selectionpower |
| spellingShingle | De Kovel Carolien The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations Genetics Selection Evolution artificial selection hitchhiking linkage disequilibrium natural selection power |
| title | The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations |
| title_full | The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations |
| title_fullStr | The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations |
| title_full_unstemmed | The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations |
| title_short | The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations |
| title_sort | power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations |
| topic | artificial selection hitchhiking linkage disequilibrium natural selection power |
| url | http://www.gsejournal.org/content/38/1/3 |
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