Differential Effects of Paraquat, Rotenone, and MPTP on Cellular Bioenergetics of Undifferentiated and Differentiated Human Neuroblastoma Cells

Differential Effects of Paraquat, Rotenone, and MPTP on Cellular Bioenergetics of Undifferentiated and Differentiated Human Neuroblastoma Cells

Paraquat (PQ), rotenone (RO), and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are neurotoxicants that can damage human health. Exposure to these neurotoxicants has been linked to neurodegeneration, particularly Parkinson’s disease. However, their mechanisms of action have not been fully eluc...

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Bibliographic Details
Main Authors: Ekramy Elmorsy, Ayat Al-Ghafari, Huda Al Doghaither, Sara Hashish, Mohamed Salama, Anusha W. Mudyanselage, Lipta James, Wayne G. Carter
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Brain Sciences
Subjects:
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
mitochondrial damage
neurotoxicity
oxidative stress
paraquat
pesticides
Online Access:https://www.mdpi.com/2076-3425/13/12/1717

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